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Assessment of Turbulent Flow Effects on the Vessel Wall Using Four-Dimensional Flow MRI
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences.ORCID iD: 0000-0003-1942-7699
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Clinical Physiology in Linköping. Linköping University, Center for Medical Image Science and Visualization (CMIV).ORCID iD: 0000-0003-1395-8296
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Clinical Physiology in Linköping. Linköping University, Center for Medical Image Science and Visualization (CMIV).
2017 (English)In: Magnetic Resonance in Medicine, ISSN 0740-3194, E-ISSN 1522-2594, Vol. 77, no 6, 2310-2319 p.Article in journal (Refereed) Published
Abstract [en]

Purpose: To explore the use of MR-estimated turbulence quantities for the assessment of turbulent flow effects on the vessel wall. Methods: Numerical velocity data for two patient-derived models was obtained using computational fluid dynamics (CFD) for two physiological flow rates. The four-dimensional (4D) Flow MRI measurements were simulated at three different spatial resolutions and used to investigate the estimation of turbulent wall shear stress (tWSS) using the intravoxel standard deviation (IVSD) of velocity and turbulent kinetic energy (TKE) estimated near the vessel wall. Results: Accurate estimation of tWSS using the IVSD is limited by the spatial resolution achievable with 4D Flow MRI. TKE, estimated near the wall, has a strong linear relationship to the tWSS (mean R(2=)0.84). Near-wall TKE estimates from MR simulations have good agreement to CFD-derived ground truth (mean R-2=0.90). Maps of near-wall TKE have strong visual correspondence to tWSS. Conclusion: Near-wall estimation of TKE permits assessment of relative maps of tWSS, but direct estimation of tWSS is challenging due to limitations in spatial resolution. Assessment of tWSS and near-wall TKE may open new avenues for analysis of different pathologies. (C) 2016 International Society for Magnetic Resonance in Medicine

Place, publisher, year, edition, pages
WILEY , 2017. Vol. 77, no 6, 2310-2319 p.
Keyword [en]
phase contrast magnetic resonance imaging; wall shear stress; turbulence; turbulent kinetic energy; aorta
National Category
Medical Image Processing
Identifiers
URN: urn:nbn:se:liu:diva-138232DOI: 10.1002/mrm.26308ISI: 000401270900022PubMedID: 27350049OAI: oai:DiVA.org:liu-138232DiVA: diva2:1109393
Note

Funding Agencies|Swedish Research Council; National Supercomputer Centre [SNIC2014-11-22]

Available from: 2017-06-14 Created: 2017-06-14 Last updated: 2017-06-28

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Ziegler, MagnusLantz, JonasEbbers, TinoDyverfeldt, Petter
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Division of Cardiovascular MedicineFaculty of Medicine and Health SciencesDepartment of Clinical Physiology in LinköpingCenter for Medical Image Science and Visualization (CMIV)
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