liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Negative interaction between smoking and EBV in the risk of multiple sclerosis: The EnvIMS study
University of Bergen, Norway; Haukeland Hospital, Norway.
University of Bergen, Norway; Haukeland Hospital, Norway.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in Central Östergötland, Department of Neurology.
University of Ferrara, Italy.
Show others and affiliations
2017 (English)In: Multiple Sclerosis, ISSN 1352-4585, E-ISSN 1477-0970, Vol. 23, no 7, 1018-1024 p.Article in journal (Refereed) Published
Abstract [en]

Background: Results from previous studies on a possible interaction between smoking and Epstein-Barr virus (EBV) in the risk of multiple sclerosis (MS) are conflicting. Objectives: To examine the interaction between smoking and infectious mononucleosis (IM) in the risk of MS. Methods: Within the case-control study on Environmental Factors In Multiple Sclerosis (EnvIMS), 1904 MS patients and 3694 population-based frequency-matched healthy controls from Norway, Italy, and Sweden reported on prior exposure to smoking and history of IM. We examined the interaction between the two exposures on the additive and multiplicative scale. Results: Smoking and IM were each found to be associated with an increased MS risk in all three countries, and there was a negative multiplicative interaction between the two exposures in each country separately as well as in the pooled analysis (p=0.001). Among those who reported IM, there was no increased risk associated with smoking (odds ratio (OR): 0.95, 95% confidence interval (CI): 0.66-1.37). The direction of the estimated interactions on the additive scale was consistent with a negative interaction in all three countries (relative excess risk due to interaction (RERI): -0.98, 95% CI: -2.05-0.15, p=0.09). Conclusion: Our findings indicate competing antagonism, where the two exposures compete to affect the outcome.

Place, publisher, year, edition, pages
SAGE PUBLICATIONS LTD , 2017. Vol. 23, no 7, 1018-1024 p.
Keyword [en]
Multiple sclerosis; epidemiology; risk factors; smoking; Epstein-Barr virus; infectious mononucleosis
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:liu:diva-138895DOI: 10.1177/1352458516671028ISI: 000402620400017PubMedID: 27663872OAI: oai:DiVA.org:liu-138895DiVA: diva2:1115935
Note

Funding Agencies|Italian MS Society/Foundation (Fondazione Italiana Sclerosi Multipla, FISM) [2007/R/14, 2008/R/19]; Western Norway Regional Health Authority (Helse Vest) Norway [911421/2008, 911474/2009]; University of Bergen, Norway; Norwegian MS society; Multiple Sclerosis Society of Canada

Available from: 2017-06-27 Created: 2017-06-27 Last updated: 2017-06-27

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Boström, IngerLandtblom, Anne-Marie
By organisation
Division of Neuro and Inflammation ScienceFaculty of Medicine and Health SciencesDepartment of NeurologyCenter for Medical Image Science and Visualization (CMIV)
In the same journal
Multiple Sclerosis
Public Health, Global Health, Social Medicine and Epidemiology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 88 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf