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DNA Commission of the International Society for Forensic Genetics ( ISFG): Guidelines on the use of X-STRs in kinship analysis
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences. National Board Forens Med, Department Forens Genet and Forens Toxicol, Artillerigatan 12, SE-58758 Linkoping, Sweden.
Oslo University Hospital, Norway.
NIST, MD 20899 USA.
Medical University of Innsbruck, Austria; Penn State University, PA 16802 USA.
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2017 (English)In: Forensic Science International: Genetics, ISSN 1872-4973, E-ISSN 1878-0326, Vol. 29, 269-275 p.Article in journal (Refereed) Published
Abstract [en]

Forensic genetic laboratories perform an increasing amount of genetic analyses of the X chromosome, in particular to solve complex cases of kinship analysis. For some biological relationships X-chromosomal markers can be more informative than autosomal markers, and there are a large number of markers, methods and databases that have been described for forensic use. Due to their particular mode of inheritance, and their physical location on a single chromosome, some specific considerations are required when estimating the weight of evidence for X-chromosomal marker DNA data. The DNA Commission of the International Society for Forensic Genetics (ISFG) hereby presents guidelines and recommendations for the use of X-chromosomal markers in kinship analysis with a special focus on the biostatistical evaluation. Linkage and linkage disequilibrium (association of alleles) are of special importance for such evaluations and these concepts and the implications for likelihood calculations are described in more detail. Furthermore it is important to use appropriate computer software that accounts for linkage and linkage disequilibrium among loci, as well as for mutations. Even though some software exist, there is still a need for further improvement of dedicated software. (C) 2017 Elsevier B.V. All rights reserved.

Place, publisher, year, edition, pages
ELSEVIER IRELAND LTD , 2017. Vol. 29, 269-275 p.
Keyword [en]
X chromosome; Linkage; Linkage disequilibrium; Haplotype; Recombination; Paternity; Kinship
National Category
Medical Genetics
Identifiers
URN: urn:nbn:se:liu:diva-138877DOI: 10.1016/j.fsigen.2017.05.005ISI: 000403086300041PubMedID: 28544956OAI: oai:DiVA.org:liu-138877DiVA: diva2:1115964
Available from: 2017-06-27 Created: 2017-06-27 Last updated: 2017-06-27

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