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Effect of simultaneous vaccination with H1N1 and GAD-alum on GAD(65)-induced immune response
Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences.
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2017 (English)In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 60, no 7, 1276-1283 p.Article in journal (Refereed) Published
Abstract [en]

Aims/hypothesis A European Phase III trial of GAD formulated with aluminiumhydroxide (GAD-alum) failed to reach its primary endpoint (preservation of stimulated C-peptide secretion from baseline to 15 months in type 1 diabetes patients), but subgroup analysis showed a clinical effect when participants from Nordic countries were excluded, raising concern as to whether the mass vaccination of the Swedish and Finnish populations with the Pandemrix influenza vaccine could have influenced the study outcomes. In the current study, we aimed to assess whether Pandemrix vaccination affects the specific immune responses induced by GAD-alum and the C-peptide response. Methods In this secondary analysis, we analysed data acquired from the Swedish participants in the Phase III GAD-alum trial who received subcutaneous GAD-alum vaccination (two doses, n = 43; four doses, n = 46) or placebo (n = 48). GAD autoantibodies (GADA) and H1N1 autoantibodies, GAD(65)-induced cytokine secretion and change in fasting and stimulated C-peptide levels from baseline to 15 months were analysed with respect to the relative time between H1N1 vaccination and the first injection of GAD-alum. Results GADA levels at 15 months were associated with the relative time between GAD-alum and Pandemrix administration in participants who received two doses of the GAD-alum vaccine (p = 0.015, r = 0.4). Both in participants treated with two doses and four doses of GAD-alum, GADA levels were higher when the relative time between vaccines was amp;gt;= 210 days (p amp;lt; 0.05). In the group that received two doses of GAD-alum, levels of several GAD(65)-induced cytokines were higher in participants who received the H1N1 vaccination and the first GADalum injection at least 150 days apart, and the change in fasting and stimulated C-peptide at 15 months was associated with the relative time between vaccines. Neither of these effects were observed in individuals who received four doses of GAD-alum. Conclusions/interpretation In individuals who received two doses of GAD-alum, receiving the Pandemrix vaccine closer to the first GAD-alum injection, i.e. amp;lt; 150 days, seemed to affect both GAD(65)-induced immune response and C-peptide preservation.

Place, publisher, year, edition, pages
SPRINGER , 2017. Vol. 60, no 7, 1276-1283 p.
Keyword [en]
Children; GAD; H1N1; Immune intervention; Type 1 diabetes; Vaccine
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:liu:diva-138875DOI: 10.1007/s00125-017-4263-xISI: 000402553400015PubMedID: 28357504OAI: oai:DiVA.org:liu-138875DiVA: diva2:1115966
Note

Funding Agencies|JDRF [17-2011-249]; Swedish Research Council [K2008-55x-20,652-01-3]; Swedish Child Diabetes Foundation (Barndiabetesfonden); Medical Research Council of Southeast Sweden; Diamyd Medical

Available from: 2017-06-27 Created: 2017-06-27 Last updated: 2017-06-27

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Tavira Iglesias, BeatrizChéramy, MikaelAxelsson Chéramy, StinaÅkerman, LindaLudvigsson, JohnnyCasas, Rosaura
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Division of Children's and Women's healthFaculty of Medicine and Health SciencesDivision of Clinical SciencesDepartment of Paediatrics in Linköping
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Diabetologia
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CiteExportLink to record
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