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Involved and Uninvolved Psoriatic Keratinocytes Display a Resistance to Apoptosis that may Contribute to Epidermal Thickness.
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Medicine and Health Sciences. (Ingrid Asp Psoriasis Research Center)
Linköping University, Department of Clinical and Experimental Medicine. Region Östergötland, Heart and Medicine Center, Department of Dermatology and Venerology. Linköping University, Faculty of Medicine and Health Sciences. (Ingrid Asp Psoriasis Research Center)
2017 (English)In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057Article in journal (Refereed) Epub ahead of print
Abstract [en]

Psoriasis is a common autoimmune skin disease. The aim of this study was to investigate whether the apoptotic process is disturbed in psoriatic keratinocytes. In vitro culture of keratinocytes derived from both involved and uninvolved psoriatic skin, revealed higher viability and resistance to apoptosis following exposure to ultraviolet B, compared with cells from healthy controls. The position of apoptotic dysregulation was found to be upstream of cytochrome c release in the mitochondrial apoptotic pathway. Microarray transcriptome analysis revealed that 87 genes were differentially expressed in both involved and uninvolved psoriatic keratinocytes compared with controls. Among these, a general upregulation of anti-apoptotic genes and downregulation of pro-apoptotic genes were identified. This distinct apoptosis-resistant phenotype, unrelated to the inflammatory component of the disease, implies that intrinsic abnormalities in keratinocytes may contribute to the pathogenesis of psoriasis.

Place, publisher, year, edition, pages
2017.
National Category
Dermatology and Venereal Diseases
Identifiers
URN: urn:nbn:se:liu:diva-139106DOI: 10.2340/00015555-2656PubMedID: 28350039OAI: oai:DiVA.org:liu-139106DiVA: diva2:1118667
Available from: 2017-07-01 Created: 2017-07-01 Last updated: 2017-07-01

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Enerbäck, Charlotta
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Department of Clinical and Experimental MedicineFaculty of Medicine and Health SciencesDepartment of Dermatology and Venerology
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