liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Organic bioelectronics in medicine
Karolinska Institute, Sweden.
Karolinska Institute, Sweden.
Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0002-5582-140X
Karolinska Institute, Sweden.
2017 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 282, no 1, 24-36 p.Article in journal (Refereed) Published
Abstract [en]

A major challenge in the growing field of bioelectronic medicine is the development of tissue interface technologies promoting device integration with biological tissues. Materials based on organic bioelectronics show great promise due to a unique combination of electronic and ionic conductivity properties. In this review, we outline exciting developments in the field of organic bioelectronics and demonstrate the medical importance of these active, electronically controllable materials. Importantly, organic bioelectronics offer a means to control cell-surface attachment as required for many device-tissue applications. Experiments have shown that cells readily attach and proliferate on reduced but not oxidized organic bioelectronic materials. In another application, the active properties of organic bioelectronics were used to develop electronically triggered systems for drug release. After incorporating drugs by advanced loading strategies, small compound drugs were released upon electrochemical trigger, independent of charge. Another type of delivery device was used to achieve well-controlled, spatiotemporal delivery of cationic drugs. Via electrophoretic transport within a polymer, cations were delivered with single-cell precision. Finally, organic bioelectronic materials are commonly used as electrode coatings improving the electrical properties of recording and stimulation electrodes. Because such coatings drastically reduce the electrode impedance, smaller electrodes with improved signal-to-noise ratio can be fabricated. Thus, rapid technological advancement combined with the creation of tiny electronic devices reacting to changes in the tissue environment helps to promote the transition from standard pharmaceutical therapy to treatment based on electroceuticals. Moreover, the widening repertoire of organic bioelectronics will expand the options for true biological interfaces, providing the basis for personalized bioelectronic medicine.

Place, publisher, year, edition, pages
WILEY , 2017. Vol. 282, no 1, 24-36 p.
Keyword [en]
bioelectronic medicine; conductive polymers; luminescent conjugated oligothiophenes; neuronal stimulation; organic bioelectronics; tissue engineering
National Category
Other Medical Engineering
Identifiers
URN: urn:nbn:se:liu:diva-139182DOI: 10.1111/joim.12595ISI: 000403441800003PubMedID: 28181720OAI: oai:DiVA.org:liu-139182DiVA: diva2:1120189
Conference
13th Key Symposium on Bioelectronic Medicine - Technology Targeting Molecular Mechanisms
Note

Funding Agencies|Swedish Medical Nanoscience Center; Swedish Research Council; Swedish Foundation for Strategic Research; Carl Bennet AB; VINNOVA; Karolinska Institutet; Erling-Persson Family Foundation

Available from: 2017-07-05 Created: 2017-07-05 Last updated: 2017-07-05

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Nilsson, Peter
By organisation
ChemistryFaculty of Science & Engineering
In the same journal
Journal of Internal Medicine
Other Medical Engineering

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 61 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf