In software development projects, bug triage consists mainly of assigning bug reports to software developers or teams (depending on the project). The partial or total automation of this task would have a positive economic impact on many software projects. This thesis introduces a systematic four-step method to find some of the best configurations of several machine learning algorithms intending to solve the automatic bug assignment problem. These four steps are respectively used to select a combination of pre-processing techniques, a bug report representation, a potential feature selection technique and to tune several classifiers. The aforementioned method has been applied on three software projects: 66 066 bug reports of a proprietary project, 24 450 bug reports of Eclipse JDT and 30 358 bug reports of Mozilla Firefox. 619 configurations have been applied and compared on each of these three projects. In production, using the approach introduced in this work on the bug reports of the proprietary project would have increased the accuracy by up to 16.64 percentage points.