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Gradient-dependent release of the model drug TRITC-dextran from FITC-labeled BSA hydrogel nanocarriers in the hair follicles of porcine ear skin
Charite, Germany.
Charite, Germany.
Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, Faculty of Science & Engineering. Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Medicine and Health Sciences.ORCID iD: 0000-0003-3274-6029
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences.
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2017 (English)In: European journal of pharmaceutics and biopharmaceutics, ISSN 0939-6411, E-ISSN 1873-3441, Vol. 116, 12-16 p.Article in journal (Refereed) Published
Abstract [en]

Hair follicle research is currently focused on the development of drug-loaded nanocarriers for the targeting of follicular structures in the treatment of skin and hair follicle-related disorders. In the present study, a dual-label nanocarrier system was implemented in which FITC-labeled BSA hydrogel nanocarriers loaded with the model drug and dye TRITC-dextran were applied topically to porcine ear skin. Follicular penetration and the distribution of both dyes corresponding to the nanocarriers and the model drug in the follicular ducts subsequent to administration to the skin were investigated using confocal laser scanning microscopy. The release of TRITC-dextran from the particles was induced by washing of the nanocarriers, which were kept in a buffer containing TRITC-labeled dextran to balance out the diffusion of the dextran during storage, thereby changing the concentration gradient. The results showed a slightly but statistically significantly deeper follicular penetration of fluorescent signals corresponding to TRITC-dextran as opposed to fluorescence corresponding to the FITC-labeled particles. The different localizations of the dyes in the cross-sections of the skin samples evidenced the release of the model drug from the labeled nanoparticles. (C) 2016 Elsevier B.V. All rights reserved.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE BV , 2017. Vol. 116, 12-16 p.
Keyword [en]
Hair follicles; Skin; Penetration; Nanocarriers; Drug delivery; Confocal laser scanning microscope
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:liu:diva-139266DOI: 10.1016/j.ejpb.2016.09.016ISI: 000403729600003PubMedID: 27693856OAI: oai:DiVA.org:liu-139266DiVA: diva2:1121150
Note

Funding Agencies|Collaborative Research Center of the German Research Foundation [1112]

Available from: 2017-07-10 Created: 2017-07-10 Last updated: 2017-07-10

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Mak, Wing CheungKwan Yee, Cheung
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Biosensors and BioelectronicsFaculty of Science & EngineeringDepartment of Clinical and Experimental MedicineFaculty of Medicine and Health SciencesDivision of Cell Biology
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European journal of pharmaceutics and biopharmaceutics
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Citation style
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