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Roles of piRNAs in microcystin-leucine-arginine (MC-LR) induced reproductive toxicity in testis on male offspring
Nanjing University, Peoples R China.
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Medicine and Health Sciences. Nanjing University, Peoples R China.
Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences. Nanjing University, Peoples R China.
Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Allergy Center.
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2017 (English)In: Food and Chemical Toxicology, ISSN 0278-6915, E-ISSN 1873-6351, Vol. 105, 177-185 p.Article in journal (Refereed) Published
Abstract [en]

In the present study, we evaluated the toxic effects on the testis of the male offspring of MC-LR exposure during fetal and lactational periods. Pregnant females were distributed into two experimental groups: control group and MC-LR group which were exposed to 0 and 10 mu g/L of MC-LR, respectively, through drinking water separately during fetal and lactational periods. At the age of 30 days after birth, the male offspring were euthanized. The body weight, testis index, and histomorphology change were observed and the global changes of piwi-interacting RNA (piRNA) expression were evaluated. The results revealed that MC-LR was found in the testis of male offspring, body weight and testis index decreased significantly, and testicular tissue structure was damaged in the MC-LR group. In addition, the exposure to MCLR resulted in an altered piRNA expression profile and an increase of the cell apoptosis and a decrease of the cell proliferation in the testis of the male offspring. It was reasonable to speculate that the toxic effects on reproductive system of the male offspring in MC-LR group might be mediated by piRNAs through the regulation of the target genes. As far as we are aware, this is the first report showing that MC-LR could play a role in disorder of proliferative and cell apoptosis in the testis of the male offspring by the maternal transmission effect of toxicity. (C) 2017 Elsevier Ltd. All rights reserved.

Place, publisher, year, edition, pages
PERGAMON-ELSEVIER SCIENCE LTD , 2017. Vol. 105, 177-185 p.
Keyword [en]
MC-LR; piRNA; Male offspring; Testis; Apoptosis; Cell proliferation
National Category
Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:liu:diva-139267DOI: 10.1016/j.fct.2017.04.014ISI: 000403625000019PubMedID: 28414124OAI: oai:DiVA.org:liu-139267DiVA: diva2:1121155
Note

Funding Agencies|National Natural Science Foundation of China [21377052, 31370524]; Doctoral Program of Higher Education (SRFDP), Ministry of Education, China [20130091110050]

Available from: 2017-07-10 Created: 2017-07-10 Last updated: 2017-07-10

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Zhang, HuiZhang, HuanBenson, Mikael
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Department of Clinical and Experimental MedicineFaculty of Medicine and Health SciencesDivision of Children's and Women's healthAllergy Center
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