liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Review of Caffeine-Related Fatalities along with Postmortem Blood Concentrations in 51 Poisoning Deaths
Region Östergötland, Center for Diagnostics, Department of Clinical Pharmacology. Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences.
2017 (English)In: Journal of Analytical Toxicology, ISSN 0146-4760, E-ISSN 1945-2403, Vol. 41, no 3, 167-172 p.Article, review/survey (Refereed) Published
Abstract [en]

Publications reporting concentrations of caffeine in postmortem blood were reviewed if the cause of death was attributed to overdosing (poisoning) with drugs. Age and gender of the deceased, the manner of death (accident, suicide or undetermined) and types of co-ingested drugs were evaluated in relation to the concentrations of caffeine in blood (N = 51). The mean age (+/- SD) of the victims was 39 +/- 17.8 years (range 18-84 years) and most were female (N = 31 or 61%). The difference in mean age ofmales (42 +/- 17.2 years) and females (37 +/- 18.3 years) was not statistically significant (t = 0.811, P = 0.421). The mean (+/- SD), median and range of caffeine concentrations in postmortem blood were 187 +/- 96mg/L (180mg/L) and 33-567mg/L, respectively. The median concentration of caffeine in males (161mg/L) was not significantly different from that of females (182mg/L), z = 1.18, P = 0.235. There was no correlation between the age of the deceased and the concentration of caffeine in postmortem blood (R-2 = 0.026, P amp;gt; 0.05). Manner of death was classified as suicide in 51% of cases (median blood-caffeine 185mg/L), accidental in 16% (median 183mg/L) or undetermined in 33% (median 113mg/L). The median concentration of caffeine in blood was lower when manner of death was undetermined compared with suicide or accidental (P = 0.023). Although other drugs, including ethanol, antidepressants, antipsychotics, benzodiazepines and/or ephedrine, were often identified in postmortem blood, the predominant psychoactive substance was caffeine. The deceased had ingested caffeine in tablet or powder form and it does not seem likely that toxic concentrations of caffeine can be achieved from over-consumption of caffeinated beverages alone.

Place, publisher, year, edition, pages
OXFORD UNIV PRESS INC , 2017. Vol. 41, no 3, 167-172 p.
National Category
Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:liu:diva-139420DOI: 10.1093/jat/bkx011ISI: 000404528000001PubMedID: 28334840OAI: oai:DiVA.org:liu-139420DiVA: diva2:1129808
Available from: 2017-08-07 Created: 2017-08-07 Last updated: 2017-08-22Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Jones, A Wayne
By organisation
Department of Clinical PharmacologyDivision of Drug ResearchFaculty of Medicine and Health Sciences
In the same journal
Journal of Analytical Toxicology
Pharmacology and Toxicology

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 38 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf