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Inhibitory rTMS of secondary somatosensory cortex reduces intensity but not pleasantness of gentle touch
NIH, MD 20892 USA.
NIH, MD 20892 USA.
NIH, MD 20892 USA.
NIAAA, MD USA.
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2017 (English)In: Neuroscience Letters, ISSN 0304-3940, E-ISSN 1872-7972, Vol. 653, 84-91 p.Article in journal (Refereed) Published
Abstract [en]

Research suggests that the discriminative and affective aspects of touch are processed differently in the brain. Primary somatosensory cortex is strongly implicated in touch discrimination, whereas insular and prefronal regions have been associated with pleasantness aspects of touch. However, the role of secondary somatosensory cortex (S2) is less clear. In the current study we used inhibitory repetitive transcranial magnetic stimulation (rTMS) to temporarily deactivate S2 and probe its role in touch perception. Nineteen healthy adults received two sessions of 1-Hz rTMS on separate days, one targeting right S2 and the other targeting the vertex (control). Before and after rTMS, subjects rated the intensity and pleasantness of slow and fast gentle brushing of the hand and performed a 2-point tactile discrimination task, followed by fMRI during additional brushing. rTMS to S2 (but not vertex) decreased intensity ratings of fast brushing, without altering touch pleasantness or spatial discrimination. MRI showed a reduced response to brushing in S2 (but not in S1 or insula) after S2 rTMS. Together, our results show that reducing touch evoked activity in S2 decreases perceived touch intensity, suggesting a causal role of S2 in touch intensity perception. Published by Elsevier Ireland Ltd.

Place, publisher, year, edition, pages
ELSEVIER IRELAND LTD , 2017. Vol. 653, 84-91 p.
Keyword [en]
Tactile; Touch; Intensity; Pleasantness; rTMS; Secondary somatosensory cortex
National Category
Physiology
Identifiers
URN: urn:nbn:se:liu:diva-139561DOI: 10.1016/j.neulet.2017.05.006ISI: 000405153900014PubMedID: 28529174OAI: oai:DiVA.org:liu-139561DiVA: diva2:1130091
Note

Funding Agencies|Intramural Research program of the NIH, National Center for Complementary and Integrative Health

Available from: 2017-08-08 Created: 2017-08-08 Last updated: 2017-08-08

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Olausson, Håkan
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Center for Social and Affective NeuroscienceFaculty of Medicine and Health Sciences
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CiteExportLink to record
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Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
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More languages
Output format
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