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GAB2 regulates type 2 T helper cell differentiation in humans
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. University of Texas MD Anderson Cancer Centre, TX 77030 USA.
Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Allergy Center.
Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences.
2017 (English)In: Cytokine, ISSN 1043-4666, E-ISSN 1096-0023, Vol. 96, 234-237 p.Article in journal (Refereed) Published
Abstract [en]

Th2 cell differentiation involves complex changes in expression of multiple genes, many of which have poorly characterized roles. In a gene expression microarray analysis of human primary CD4(+) effector T subsets, we identified that an adaptor protein, GAB2, was preferentially expressed in human Th2 cells. The role of GAB2 in human Th2 cells is unknown. Through analysis of primary and in vitro differentiated human T effector subsets, we confirmed that human Th2 cells preferentially expressed GAB2. Further analysis of public gene expression microarray data of STAT6-knockdowned Th2 cells indicated that GAB2 expression was regulated by IL-4 and STAT6. Both siRNA knockdown and ectopic expression of GAB2 in activated T cells showed that GAB2 positively regulated IL-4 and IL-13 expression in human Th2 cells. We hence identified the adaptor protein, GAB2, as an important novel regulator of the human Th2 immune response.

Place, publisher, year, edition, pages
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD , 2017. Vol. 96, 234-237 p.
Keyword [en]
GAB2; T helper 2 cells; Immune response; Differentiation
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:liu:diva-139526DOI: 10.1016/j.cyto.2017.04.027ISI: 000405042800032PubMedID: 28477539OAI: oai:DiVA.org:liu-139526DiVA: diva2:1130183
Note

Funding Agencies|Swedish Research Council [2015-02575, 2013-00324]

Available from: 2017-08-08 Created: 2017-08-08 Last updated: 2017-08-08

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