The Global ECT-MRI Research Collaboration (GEMRIC): Establishing a multi-site investigation of the neural mechanisms underlying response to electroconvulsive therapyUniversity of New Mexico, NM 87131 USA.
VUmc Amsterdam, Netherlands.
VUmc Amsterdam, Netherlands.
Haukeland Hospital, Norway.
Katholieke University of Leuven, Belgium.
Donders Institute Brain Cognit and Behav, Netherlands.
Feinstein Institute Medical Research, NY USA.
Donders Institute Brain Cognit and Behav, Netherlands.
Linköping University, Department of Clinical and Experimental Medicine, Center for Social and Affective Neuroscience. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in Central Östergötland, Department of Psychiatry.
Linköping University, Department of Clinical and Experimental Medicine, Center for Social and Affective Neuroscience. Linköping University, Faculty of Medicine and Health Sciences.
Psychiat Centre Copenhagen, Denmark.
University of Medical Centre, Netherlands.
University of Medical Centre, Netherlands.
University of Lausanne, Switzerland; Max Planck Institute Human Brain and Cognit Neurosci, Germany.
Department of Psychiatry, University of Münster, Germany.
University of Munster, Germany; University of Marburg, Germany.
University of Munster, Germany.
Katholieke University of Leuven, Belgium.
Katholieke University of Leuven, Belgium.
Cleveland Clin, OH 44106 USA.
University of Calif Los Angeles, CA USA.
University of Calif Los Angeles, CA 90024 USA.
University of Calif San Diego, CA 92037 USA; University of Calif San Diego, CA 92093 USA.
University of Calif San Diego, CA 92037 USA; University of Calif San Diego, CA 92093 USA; University of Calif San Diego, CA 92093 USA.
University of Bergen, Norway; Haukeland Hospital, Norway; KG Jebsen Centre Research Neuropsychiat Disorders, Norway.
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2017 (English)In: NeuroImage: Clinical, E-ISSN 2213-1582, Vol. 14, p. 422-432Article in journal (Refereed) Published
Abstract [en]
Major depression, currently the worlds primary cause of disability, leads to profound personal suffering and increased risk of suicide. Unfortunately, the success of antidepressant treatment varies amongst individuals and can take weeks to months in those who respond. Electroconvulsive therapy (ECT), generally prescribed for the most severely depressed and when standard treatments fail, produces a more rapid response and remains the most effective intervention for severe depression. Exploring the neurobiological effects of ECT is thus an ideal approach to better understand the mechanisms of successful therapeutic response. Though several recent neuroimaging studies show structural and functional changes associated with ECT, not all brain changes associate with clinical outcome. Larger studies that can address individual differences in clinical and treatment parameters may better target biological factors relating to or predictive of ECT-related therapeutic response. We have thus formed the Global ECT-MRI Research Collaboration (GEMRIC) that aims to combine longitudinal neuroimaging as well as clinical, behavioral and other physiological data across multiple independent sites. Here, we summarize the ECT sample characteristics from currently participating sites, and the common data-repository and standardized image analysis pipeline developed for this initiative. This includes data harmonization across sites and MRI platforms, and a method for obtaining unbiased estimates of structural change based on longitudinal measurements with serial MRI scans. The optimized analysis pipeline, together with the large and heterogeneous combined GEMRIC dataset, will provide new opportunities to elucidate the mechanisms of ECT response and the factors mediating and predictive of clinical outcomes, which may ultimately lead to more effective personalized treatment approaches. (C) 2017 The Author(s). Published by Elsevier Inc.
Place, publisher, year, edition, pages
ELSEVIER SCI LTD , 2017. Vol. 14, p. 422-432
Keywords [en]
Electroconvulsive therapy; MRI; Longitudinal; Mega analysis; Multi-site
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:liu:diva-139647DOI: 10.1016/j.nicl.2017.02.009ISI: 000405984300045PubMedID: 28275543OAI: oai:DiVA.org:liu-139647DiVA, id: diva2:1133701
Note
Funding Agencies|Western Norway Regional Health Authority; Haukeland University Hospital; University of Bergen, Norway; Lundbeck Foundation; German Research Foundation (DFG) [FOR2107, 1151/5-1]; Innovative Medizinische Forschung (IMF) [RE111604]; Centers of Biomedical Research Excellence [2P20GM103472-01]; Swiss National Science Foundation (NCCR Synapsy) [32003B_159780]; Foundation Parkinson Switzerland; Foundation Synapsis; Roger de Spoelberch Foundation; National Institute of Mental Health [R01MH092301, K24MH102743]; Partridge Foundation
2017-08-162017-08-162024-01-17