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Involved and Uninvolved Psoriatic Keratinocytes Display a Resistance to Apoptosis that may Contribute to Epidermal Thickness
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Dermatology and Venerology.
2017 (English)In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 97, no 7, p. 788-796Article in journal (Refereed) Published
Abstract [en]

Psoriasis is a common autoimmune skin disease. The aim of this study was to investigate whether the apoptotic process is disturbed in psoriatic keratinocytes. In vitro culture of keratinocytes derived from both involved and uninvolved psoriatic skin, revealed higher viability and resistance to apoptosis following exposure to ultraviolet B, compared with cells from healthy controls. The position of apoptotic dysregulation was found to be upstream of cytochrome c release in the mitochondrial apoptotic pathway. Microarray transcriptome analysis revealed that 87 genes were differentially expressed in both involved and uninvolved psoriatic keratinocytes compared with controls. Among these, a general upregulation of anti-apoptotic genes and downregulation of pro-apoptotic genes were identified. This distinct apoptosis-resistant phenotype, unrelated to the inflammatory component of the disease, implies that intrinsic abnormalities in keratinocytes may contribute to the pathogenesis of psoriasis.

Place, publisher, year, edition, pages
ACTA DERMATO-VENEREOLOGICA , 2017. Vol. 97, no 7, p. 788-796
Keywords [en]
psoriasis; keratinocytes; apoptosis
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:liu:diva-139820DOI: 10.2340/00015555-2656ISI: 000405580200004PubMedID: 28350039OAI: oai:DiVA.org:liu-139820DiVA, id: diva2:1133877
Note

Funding Agencies|Swedish Research Council; Ingrid Asp Foundation; Welander Foundation; Swedish Psoriasis Association

Available from: 2017-08-17 Created: 2017-08-17 Last updated: 2018-01-13

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