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Low circulating microRNA levels in heart failure patients are associated with atherosclerotic disease and cardiovascular-related rehospitalizations
University of Medical Centre Groningen, Netherlands.
University of Medical Centre Groningen, Netherlands; University of Groningen, Netherlands.
University of Medical Centre Groningen, Netherlands.
Linköping University, Department of Social and Welfare Studies, Division of Nursing Science. Linköping University, Faculty of Medicine and Health Sciences.
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2017 (English)In: Clinical Research in Cardiology, ISSN 1861-0684, E-ISSN 1861-0692, Vol. 106, no 8, p. 598-609Article in journal (Refereed) Published
Abstract [en]

Objective Circulating microRNAs (miRNAs) have been implicated in both heart failure and atherosclerotic disease. The aim of this study was to examine associations between heart failure specific circulating miRNAs, atherosclerotic disease and cardiovascular-related outcome in patients with heart failure. Methods The levels of 11 heart failure-specific circulating miRNAs were compared in plasma of 114 heart failure patients with and without different manifestations of atherosclerotic disease. We then studied these miRNAs in relation to biomarkers associated to atherosclerosis and to cardiovascular-related rehospitalizations during 18 months of follow-up. Results At least one manifestation of atherosclerotic disease was found in 70 (61%) of the heart failure patients. A consistent trend was found between an increasing number of manifestations of atherosclerosis (peripheral arterial disease in specific), and lower levels of miR-18a-5p, miR27a-3p, miR-199a-3p, miR-223-3p and miR-652-3p (all P amp;lt; 0.05). Target prediction and network analyses identified several interactions between miRNA targets and biomarkers related to inflammation, angiogenesis and endothelial dysfunction. Lower miRNA levels were associated with higher levels of these atherosclerosis-related biomarkers. In addition, lower miRNA levels were significantly associated with rehospitalizations due to cardiovascular causes within 18 months, with let-7i-5p as strongest predictor [HR 2.06 (95% CI 1.29-3.28), C-index 0.70, P = 0.002]. Conclusions A consistent pattern of lower levels of circulating miRNAs was found in heart failure patients with atherosclerotic disease, in particular peripheral arterial disease. In addition, lower levels of miRNAs were associated with higher levels of biomarkers involved in atherosclerosis and an increased risk of a cardiovascular-related rehospitalization.

Place, publisher, year, edition, pages
SPRINGER HEIDELBERG , 2017. Vol. 106, no 8, p. 598-609
Keywords [en]
Circulating microRNAs; Heart failure; Atherosclerosis; Biomarkers; Rehospitalization
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:liu:diva-139808DOI: 10.1007/s00392-017-1096-zISI: 000406276300005PubMedID: 28293796OAI: oai:DiVA.org:liu-139808DiVA, id: diva2:1133918
Note

Funding Agencies|Netherlands CardioVascular Research Initiative: the Netherlands Heart Foundation; Dutch Federation of University Medical Centres; Netherlands Organization for Health Research and Development; Royal Netherlands Academy of Sciences; Netherlands Heart Foundation: Approaching Heart Failure By Translational Research Of RNA Mechanisms (ARENA) [CVON-2011-11]; Netherlands Heart Foundation [2000Z003]; Biosite France SAS, Jouy-en-Josas, France; Roche Diagnostics Nederland BV, Venlo, the Netherlands; Novartis Pharma BV, Arnhem, the Netherlands

Available from: 2017-08-17 Created: 2017-08-17 Last updated: 2017-09-05

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