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Evaluation of a multi-layer diffuse reflectance spectroscopy system using optical phantoms
Linköping University, Department of Biomedical Engineering, Division of Biomedical Engineering. Linköping University, Faculty of Science & Engineering. Perimed AB, Sweden.ORCID iD: 0000-0002-3454-6576
University of Calif Irvine, CA USA; University of Calif Irvine, CA USA.
University of Calif Irvine, CA USA.
Linköping University, Department of Biomedical Engineering, Division of Biomedical Engineering. Linköping University, Faculty of Science & Engineering. University of Calif Irvine, CA USA; University of Calif Irvine, CA USA.
2017 (English)In: DESIGN AND QUALITY FOR BIOMEDICAL TECHNOLOGIES X, SPIE-INT SOC OPTICAL ENGINEERING , 2017, Vol. 10056, UNSP 100560GConference paper, Published paper (Refereed)
Abstract [en]

A fiber probe-based device for assessing microcirculatory parameters, especially red blood cell (RBC) tissue fraction, their oxygen saturation and speed resolved perfusion, has been evaluated using state-of-the-art multi-layer tissue simulating phantoms. The device comprises both diffuse reflectance spectroscopy (DRS) at two source-detector separations (0.4 and 1.2 mm) and laser Doppler flowmetry (LDF) and use an inverse Monte Carlo method for identifying the parameters of a multi-layered tissue model. First, model parameters affecting scattering, absorption and geometrical parameters are fitted to measured DRS spectra, then speed parameters are fitted to LDF spectra. In this paper, the accuracy of the spectral parameters is evaluated. The measured spectral shapes at the two source-detector separations were in good agreement with forward calculated spectral shapes. In conclusion, the multi-layer skin model based on spectral features of the included chromophores, can reliably estimate the tissue fraction of RBC, its oxygen saturation and the reduced scattering coefficient spectrum of the tissue. Furthermore, it was concluded that some freedom in the relative intensity difference between the two DRS channels is necessary in order to compensate for non-modeled surface structure effects.

Place, publisher, year, edition, pages
SPIE-INT SOC OPTICAL ENGINEERING , 2017. Vol. 10056, UNSP 100560G
Series
Proceedings of SPIE, ISSN 0277-786X
Keyword [en]
Diffuse reflectance spectroscopy; Optical phantoms; Multilayered tissue model; Microcirculation; Surface structure; Inverse Monte Carlo; Sampling volume
National Category
Medical Laboratory and Measurements Technologies
Identifiers
URN: urn:nbn:se:liu:diva-140077DOI: 10.1117/12.2249562ISI: 000407038900008ISBN: 978-1-5106-0553-4 (print)ISBN: 978-1-5106-0554-1 (electronic)OAI: oai:DiVA.org:liu-140077DiVA: diva2:1136580
Conference
Conference on Design and Quality for Biomedical Technologies X
Note

Funding Agencies|Swedens innovation agency VINNOVA [201602211]; VINNMER Marie Curie Academy Outgoing [2015-01503]; Fulbright Visiting Scholar; Beckman Foundation; NIH from NIBIB [P41EB015890]

Available from: 2017-08-28 Created: 2017-08-28 Last updated: 2017-08-28

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Fredriksson, IngemarStrömberg, Tomas
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