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First-in-human trials on genome editing: Strategies for handling uncertainty about benefit and uncertainty about harm
Linköping University, Department of Culture and Communication, Arts and Humanities. Linköping University, Faculty of Arts and Sciences.
2017 (English)Conference paper, Oral presentation with published abstract (Refereed)
Abstract [en]

Human genome editing can be carried out on somatic cells as well as on the germline. In this paper I discuss first-in-human trials on both types of editing. At first sight, risk and risk/benefit assessment might seem to be key issues in such trials. However, according to decision theory, risk presupposes numerical values. In ‘decision-making under risk’, decisionmakers have sufficient information to assign probabilities to alternative outcomes. This is not the case in first-in-human trials. These trials are rather characterized by ‘decision-making under uncertainty’. My overall objective is to clarify the implications of uncertainty about benefit and uncertainty about harm in first-in-human trials on genome editing. A special aim is to analyse strategies for handling uncertainty.

Place, publisher, year, edition, pages
2017. 11-12 p.
National Category
Humanities and the Arts Medical Ethics Philosophy Cancer and Oncology Environmental Sciences related to Agriculture and Land-use
Identifiers
URN: urn:nbn:se:liu:diva-140494OAI: oai:DiVA.org:liu-140494DiVA: diva2:1138398
Conference
The international conference “Genome Editing: Biomedical and Ethical Perspectives” organized by Center for the study of bioethics in collaboration with New York University Langone Health and the Hastings Center, Belgrade, Serbia, August 20-21, 2017
Available from: 2017-09-05 Created: 2017-09-05 Last updated: 2017-10-13Bibliographically approved

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  • nn-NB
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Output format
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