Bisphosphonate coating on titanium screws increases mechanical fixation in rat tibia after two weeks
2008 (English)In: Journal of Biomedical Materials Research. Part A, ISSN 1549-3296, Vol. 86A, no 1, 220-227 p.Article in journal (Refereed) Published
Recently published data indicate that immobilized N-bisphosphonate enhances the pullout force and energy uptake of implanted stainless steel screws at 2 weeks in rat tibia. This study compares titanium screws with and without a bisphosphonate coating in the same animal model. The screws were first coated with an 100-nm thick crosslinked fibrinogen film. Pamidronate was subsequently immobilized into this film via EDC/NHS-activated carboxyl groups within the fibrinogen matrix, and finally another N-bisphosphonate, ibandronate, was physically adsorbed. The release kinetics of immobilized 14C-alendronate was measured in buffer up to 724 h and showed a 60% release within 8 h. Mechanical tests demonstrated a 32% (p = 0.04) and 48% (p = 0.02) larger pullout force and energy until failure after 2 weeks of implantation, compared to uncoated titanium screws. A control study with physically adsorbed pamidronate showed no effect on mechanical fixation, probably due to a too small adsorbed amount. We conclude that the fixation of titanium implants in bone can be improved by fibrinogen matrix-bound bisphosphonates.
Place, publisher, year, edition, pages
Hoboken, NJ, United States: John Wiley & Sons, 2008. Vol. 86A, no 1, 220-227 p.
Bisphosphonate, pull-out, titanium, drug release, gamma sterilization, stainless steel, rat, fibrinogen, coating
IdentifiersURN: urn:nbn:se:liu:diva-15307DOI: 10.1002/jbm.a.31583ISI: 000256459500021OAI: oai:DiVA.org:liu-15307DiVA: diva2:113870