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Temperature-corrected post-mortem 1.5 T MRI quantification of non-pathologic upper abdominal organs
University of Bern, Switzerland.
University of Bern, Switzerland.
University of Bern, Switzerland.
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Radiology in Linköping. Linköping University, Center for Medical Image Science and Visualization (CMIV).ORCID iD: 0000-0002-9446-6981
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2017 (English)In: International journal of legal medicine, ISSN 0937-9827, E-ISSN 1437-1596, Vol. 131, no 5, p. 1369-1376Article in journal (Refereed) Published
Abstract [en]

The present study aimed to evaluate if simultaneous temperature-corrected T1, T2, and proton density (PD) 1.5 T post-mortem MR quantification [quantitative post-mortem magnetic resonance imaging (QPMMRI)] is feasible for characterizing and discerning non-pathologic upper abdominal organs (liver, spleen, pancreas, kidney) with regard to varying body temperatures. QPMMRI was performed on 80 corpses (25 females, 55 males; mean age 56.2 years, SD 17.2) prior to autopsy. Core body temperature was measured during QPMMRI. Quantitative T1, T2, and PD values were measured in the liver, pancreas, spleen, and left kidney and temperature corrected to 37 A degrees C. Histologic examinations were conducted on each measured organ to determine non-pathologic organs. Quantitative T1, T2, and PD values of non-pathologic organs were ANOVA tested against values of other non-pathologic organ types. Based on temperature-corrected quantitative T1, T2, and PD values, ANOVA testing verified significant differences between the non-pathologic liver, spleen, pancreas, and left kidneys. Temperature-corrected 1.5 T QPMMRI based on T1, T2, and PD values may be feasible for characterization and differentiation of the non-pathologic liver, spleen, pancreas, and kidney. The results may provide a base for future specific pathology diagnosis of upper abdominal organs in post-mortem imaging.

Place, publisher, year, edition, pages
SPRINGER , 2017. Vol. 131, no 5, p. 1369-1376
Keywords [en]
Post-mortem magnetic resonance imaging; Post-mortem MRI quantification; Abdominal organs; Relaxation times; Proton density
National Category
Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:liu:diva-140787DOI: 10.1007/s00414-017-1622-6ISI: 000407735100026PubMedID: 28624986OAI: oai:DiVA.org:liu-140787DiVA, id: diva2:1140990
Available from: 2017-09-13 Created: 2017-09-13 Last updated: 2024-01-17

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Persson, AndersWarntjes, Marcel Jan BertusZech, Wolf-Dieter
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Division of Radiological SciencesFaculty of Medicine and Health SciencesDepartment of Radiology in LinköpingCenter for Medical Image Science and Visualization (CMIV)Division of Cardiovascular MedicineDepartment of Clinical Physiology in Linköping
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International journal of legal medicine
Pharmacology and Toxicology

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