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Vitamin D status in young Swedish women with anorexia nervosa during intensive weight gain therapy
Gothenburg University, Sweden.
Gothenburg University, Sweden.
Gothenburg University, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Chemistry.
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2017 (English)In: European Journal of Nutrition, ISSN 1436-6207, E-ISSN 1436-6215, Vol. 56, no 6, 2061-2067 p.Article in journal (Refereed) Published
Abstract [en]

Purpose Anorexia nervosa (AN) is associated with reduced bone mass and an increased fracture risk. The aim was to evaluate the vitamin D status and the association with body mass index (BMI), fat mass and bone mineral density (BMD) in patients with severe AN during a prospective intervention study of intensive nutrition therapy. Methods This study comprised 25 Swedish female AN patients (20.1 +/- 2.3 years), who were treated as inpatients for 12 weeks with a high-energy diet. Serum 25-hydroxy-vitamin D (25(OH) D), calcium, phosphate and parathyroid hormone (PTH) were measured. BMD and body composition were assessed by dual-energy X-ray absorptiometry at study start and after 12 weeks. Results Twenty-two patients completed the study. The mean weight gain was 9.9 kg and BMI (mean +/- SD) increased from 15.5 +/- 0.9 to 19.0 +/- 0.9 kg/m(2), P amp;lt; 0.0001. Fat mass increased from median 12 to 27 %. The median serum 25(OH) D level was 84 nmol/L at baseline, which decreased to 76 nmol/L, P amp;lt; 0.05. PTH increased from median 21.9 to 30.0 ng/L, P amp;lt; 0.0001. BMC increased during the study period, P amp;lt; 0.001. Conclusions Serum 25(OH) D levels were adequate both at study start and completion, however, nominally decreased after the 12-week nutritional intervention. PTH increased subsequently, which coincide with the decreased 25(OH) D levels. The reduction in 25(OH) D could be due to an increased storage of vitamin D related to the increase in fat mass since vitamin D is sequestered in adipose tissue.

Place, publisher, year, edition, pages
SPRINGER HEIDELBERG , 2017. Vol. 56, no 6, 2061-2067 p.
Keyword [en]
Vitamin D; Anorexia nervosa; Nutrition therapy; Bone
National Category
Nutrition and Dietetics
Identifiers
URN: urn:nbn:se:liu:diva-140954DOI: 10.1007/s00394-016-1244-7ISI: 000408715500006PubMedID: 27307256OAI: oai:DiVA.org:liu-140954DiVA: diva2:1142418
Note

Funding Agencies|Queen Silvia Childrens Hospital Research Foundation; Capio Foundation; Samariten Foundation; Region Ostergotland; Sahlgrenska University Hospital; Health & Medical Care Committee of the Regional Executive Board Region Vastra Gotaland; Governmental University Hospital (ALF)

Available from: 2017-09-19 Created: 2017-09-19 Last updated: 2017-09-19

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Magnusson, Per
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Division of Microbiology and Molecular MedicineFaculty of Medicine and Health SciencesDepartment of Clinical Chemistry
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