liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Characteristics of the pre-diabetic period in children with high risk of type 1 diabetes recruited from the general Swedish populationThe ABIS study
Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Linköping.
Lund University, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences.
2017 (English)In: Diabetes/Metabolism Research Reviews, ISSN 1520-7552, E-ISSN 1520-7560, Vol. 33, no 6, e2900Article in journal (Refereed) Published
Abstract [en]

BackgroundThere is a need for increased understanding of the pre-diabetic period in individuals with high risk of type 1 diabetes from the general population. MethodsHigh-risk children (n=21) positive for multiple islet autoantibodies were identified by autoantibody screening within the All Babies in Southeast Sweden study. The children and their parents were enrolled in a 2-year prospective follow-up study aiming to characterize the pre-diabetic period. Blood samples were collected every 6months for measurement of C-peptide, HbA1c, fasting glucose, and autoantibodies. Human leukocyte antigen-genotype was determined, and oral glucose tolerance test was performed every 12months. ResultsDespite positivity for multiple autoantibodies, 9 out of 21 individuals had low-risk human leukocyte antigen-genotypes. Children who progressed to manifest diabetes (progressors, n=12) had higher levels of IA2A and ZnT8A than children who did not (non-progressors, n=9). Impaired glucose tolerance and impaired fasting glucose was observed to the same extent in progressors and non-progressors, but HbA1c increased over time in progressors in spite of increased C-peptide. ConclusionsAutoantibodies to IA2 and ZnT8 may be useful discriminators for disease progression in at-risk children from the general population. Dysglycemia was observed long before diagnosis, and difficulties in maintaining glucose homeostasis despite increased C-peptide indicate that insulin resistance might be an important accelerator of disease in risk individuals.

Place, publisher, year, edition, pages
WILEY , 2017. Vol. 33, no 6, e2900
Keyword [en]
islet autoantibodies; pre-diabetes; T1D high-risk; type 1 diabetes
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:liu:diva-141128DOI: 10.1002/dmrr.2900ISI: 000409108000006PubMedID: 28371132OAI: oai:DiVA.org:liu-141128DiVA: diva2:1144753
Note

Funding Agencies|Vetenskapsradet [VR 2009-2010]; Novo Nordisk; Barndiabetesfonden; ALF Grant Region Ostergotland; ALF Grant Medical Research Council of Southeast Sweden (Forskningsradet i sydostra sverige, FORSS) [12594]

Available from: 2017-09-27 Created: 2017-09-27 Last updated: 2017-09-27

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Åkerman, LindaLudvigsson, JohnnyCasas, Rosaura
By organisation
Division of Children's and Women's healthFaculty of Medicine and Health SciencesDepartment of Paediatrics in Linköping
In the same journal
Diabetes/Metabolism Research Reviews
Endocrinology and Diabetes

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 6 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf