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Using a spontaneous profile rather than stimulation test makes the KIGS idiopathic growth hormone deficiency model more accessible for clinicians
Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Linköping.
Pfizer, Sweden.
Pfizer, Sweden.
Umeå University, Sweden.
2017 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 106, no 9, 1481-1486 p.Article in journal (Refereed) Published
Abstract [en]

Aim: Children treated with a growth hormone (GH) for idiopathic growth hormone deficiency (IGHD) may be monitored with the first-year prediction model from the Pfizer International Growth Database (KIGS) using auxology, age, GH dose and the maximum GH concentration from a stimulation test (GH(max)stim). We tested the hypothesis that using a 12-hour spontaneous profile (GH(max)12h) would be as accurate. Methods: We studied 98 prepubertal Swedish children (78boys) aged2-12 years enrolled in KIGS. The first-year growth was predicted using the GH(max) from the GHprofile and a stimulation test, and both of these were compared separately with the observed growth response. Results: The increased height observed in the first year was 0.74 standard deviation scores (SDS), and the studentised residuals for the predicted and observed growth with GH(max)stim (-0.16 SDS) and GH(max)12h (-0.22) were similar. Individual predictions calculated with stimulated or spontaneous GH(max) showed a significant correlation (r = 0.80). Conclusion: We validated the KIGS IGHD prediction model and found that the stimulated GH(max) peak can be reliably replaced by the GH(max) 12h with similar accuracy. This makes the model more accessible for clinicians, who can then provide realistic expectations for the growth response during the first year of treatment.

Place, publisher, year, edition, pages
WILEY , 2017. Vol. 106, no 9, 1481-1486 p.
Keyword [en]
Growth hormone treatment; Growth response; Idiopathic growth hormone deficiency; Prediction model; Short stature
National Category
Pediatrics
Identifiers
URN: urn:nbn:se:liu:diva-141123DOI: 10.1111/apa.13932ISI: 000409343900018PubMedID: 28543706OAI: oai:DiVA.org:liu-141123DiVA: diva2:1144759
Note

Funding Agencies|Pfizer

Available from: 2017-09-27 Created: 2017-09-27 Last updated: 2017-09-27

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Duchén, Karel
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Division of Children's and Women's healthFaculty of Medicine and Health SciencesDepartment of Paediatrics in Linköping
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CiteExportLink to record
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