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DNA methylation profiles in red blood cells of adult hens correlatewith their rearing conditions
Linköping University, Department of Physics, Chemistry and Biology, Biology. (Etologi)
Norwegian University of Life Sciences.
Norwegian University of Life Sciences.
University of São Paulo.
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2017 (English)In: Journal of Experimental Biology, ISSN 0022-0949, E-ISSN 1477-9145, Vol. 220, 3579-3587 p.Article in journal (Refereed) Published
Abstract [en]

Stressful conditions are common in the environment where productionanimals are reared. Stress in animals is usually determined by thelevels of stress-related hormones. A big challenge, however, is indetermining the history of exposure of an organism to stress, becausethe release of stress hormones can show an acute (and recent) but nota sustained exposure to stress. Epigenetic tools provide an alternativeoption to evaluate past exposure to long-termstress. Chickens providea unique model to study stress effects in the epigenome of red bloodcells (RBCs), a cell type of easy access and nucleated in birds. Thepresent study investigated whether two different rearing conditions inchickens can be identified by looking at DNA methylation patterns intheir RBCs later in life. These conditions were rearing in open aviariesversus in cages, which are likely to differ regarding the amount of stressthey generate. Our comparison revealed 115 genomic windows withsignificant changes in RBC DNA methylation between experimentalgroups, which were located around 53 genes and within 22 intronicregions. Our results set the ground for future detection of long-termstress in live production animals by measuring DNA methylation in acell type of easy accessibility.

Place, publisher, year, edition, pages
2017. Vol. 220, 3579-3587 p.
Keyword [en]
Erythrocytes, Epigenetics, Chicken, Stress, Animal welfare, Production animals
National Category
Behavioral Sciences Biology
Identifiers
URN: urn:nbn:se:liu:diva-141811DOI: 10.1242/jeb.157891OAI: oai:DiVA.org:liu-141811DiVA: diva2:1147633
Available from: 2017-10-06 Created: 2017-10-06 Last updated: 2017-10-06

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Pértille, FábioJensen, PerGuerrero Bosagna, Carlos
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CiteExportLink to record
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Citation style
  • apa
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  • modern-language-association-8th-edition
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More styles
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