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Time to remission from mild to moderate depressive symptoms: One year results from the EVIDENT-study, an RCT of an internet intervention for depression.
Department of Psychiatry and Psychotherapy, Lübeck University, Lübeck, Germany.
Department of Psychiatry and Psychotherapy, Lübeck University, Lübeck, Germany.
Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
GAIA AG, Hamburg, Germany; Department of Psychology, City, University of London, London, United Kingdom.
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2017 (English)In: Behaviour Research and Therapy, ISSN 0005-7967, E-ISSN 1873-622X, Vol. 97, p. 154-162Article in journal (Refereed) Published
Abstract [en]

Background: Internet interventions are effective in treating depressive symptoms but few studies conducted a long-term follow-up. The aim of this study was to test the effectiveness of an internet intervention in increasing the remission rate over a twelve months period.less thanbr /greater thanMethods: A total of 1013 participants with mild to moderate depressive symptoms were randomized to either care as usual alone or a 12-week internet intervention (Deprexis) plus usual care. Self-rated depression severity (PHQ-9) was assessed regularly over twelve months.less thanbr /greater thanResults: Remission rates over time were significantly higher in the intervention group (Cox regression: hazard ratio [HR] 1.31; p = 0.009). The intervention was more effective in the subgroup not taking antidepressant medication (Cox regression: HR 1.88; p less than 0.001). PHQ-change from baseline was greater in the intervention group (linear mixed model [LMM]: p less than 0.001) with the between-group effect gradually decreasing from d = 0.36 at three months to d = 0.13 at twelve months (LMM: group by time interaction: p less than 0.001).less thanbr /greater thanConclusion: This internet intervention can contribute to achieving remission in people with mild to moderate depressive symptoms, especially if they are not on antidepressant medication (Trial Registration: NCT01636752).less thanbr /greater than (Copyright © 2017 Elsevier Ltd. All rights reserved.)

Place, publisher, year, edition, pages
2017. Vol. 97, p. 154-162
National Category
Physiotherapy
Identifiers
URN: urn:nbn:se:liu:diva-141849DOI: 10.1016/j.brat.2017.07.013ISI: 000412258200016PubMedID: 28797829OAI: oai:DiVA.org:liu-141849DiVA, id: diva2:1147993
Note

Funding agencies: German Federal Ministry of Health [II A 5 - 2512 FSB 052]

Available from: 2017-10-09 Created: 2017-10-09 Last updated: 2021-07-27

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