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Time to remission from mild to moderate depressive symptoms: One year results from the EVIDENT-study, an RCT of an internet intervention for depression.
Department of Psychiatry and Psychotherapy, Lübeck University, Lübeck, Germany. Electronic address: philipp.klein@uksh.de..
Department of Psychiatry and Psychotherapy, Lübeck University, Lübeck, Germany..
Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany..
GAIA AG, Hamburg, Germany; Department of Psychology, City, University of London, London, United Kingdom..
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2017 (English)In: Behaviour Research and Therapy, ISSN 0005-7967, E-ISSN 1873-622X, Vol. 97, StartPage-EndPage p.Article in journal (Refereed) Published
Abstract [en]

Background: Internet interventions are effective in treating depressive symptoms but few studies conducted a long-term follow-up. The aim of this study was to test the effectiveness of an internet intervention in increasing the remission rate over a twelve months period.less thanbr /greater thanMethods: A total of 1013 participants with mild to moderate depressive symptoms were randomized to either care as usual alone or a 12-week internet intervention (Deprexis) plus usual care. Self-rated depression severity (PHQ-9) was assessed regularly over twelve months.less thanbr /greater thanResults: Remission rates over time were significantly higher in the intervention group (Cox regression: hazard ratio [HR] 1.31; p = 0.009). The intervention was more effective in the subgroup not taking antidepressant medication (Cox regression: HR 1.88; p less than 0.001). PHQ-change from baseline was greater in the intervention group (linear mixed model [LMM]: p less than 0.001) with the between-group effect gradually decreasing from d = 0.36 at three months to d = 0.13 at twelve months (LMM: group by time interaction: p less than 0.001).less thanbr /greater thanConclusion: This internet intervention can contribute to achieving remission in people with mild to moderate depressive symptoms, especially if they are not on antidepressant medication (Trial Registration: NCT01636752).less thanbr /greater than (Copyright © 2017 Elsevier Ltd. All rights reserved.)

Place, publisher, year, edition, pages
: Oxford [etc.] , 2017. Vol. 97, StartPage-EndPage p.
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Physiotherapy
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URN: urn:nbn:se:liu:diva-141849DOI: 10.1016/j.brat.2017.07.013OAI: oai:DiVA.org:liu-141849DiVA: diva2:1147993
Available from: 2017-10-09 Created: 2017-10-09 Last updated: 2017-10-09

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CiteExportLink to record
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