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Dynamic regulation of epithelial cell fate and barrier function by intercellular junctions
Department of Pathology & Laboratory Medicine, Emory University School of Medicine, Atlanta, GA.
Department of Pathology & Laboratory Medicine, Emory University School of Medicine, Atlanta, GA.
2009 (English)In: Annals of the New York Academy of Sciences, ISSN 0077-8923, E-ISSN 1749-6632, Vol. 1165, 220-227 p.Article in journal (Refereed) Published
Abstract [en]

In the intestine, a single layer of epithelial cells effectively separates potentially harmful luminal content from the underlying tissue. The importance of an intact mucosal layer is highlighted by pathological disorders of the gut such as inflammatory bowel disease, in which disruption of the epithelial barrier leads to severe inflammation of the submucosal tissue compartments. Epithelial barrier function is provided by tightly regulated intercellular junctions, which consist of a plethora of membrane-associated and transmembrane proteins organized in discreet, spatially restricted complexes. Classically, these complexes are known to be dynamic seals for fluids and small molecules, as well as to provide mechanical strength by anchoring cell-cell contacts to the cytoskeleton. Rather than just acting as simple gates and adapters, however, junctional complexes themselves can relay extracellular stimuli to the epithelium and initiate cellular responses such as differentiation and apoptosis. In this review, we will highlight recent studies by our group and others which discuss how junctional proteins can promote outside-to-inside signaling and modulate epithelial cell fate. Unraveling the complex crosstalk between epithelial cells and their intercellular junctions is essential to understanding how epithelial barrier function is maintained in vivo and might provide new strategies for the treatment of inflammatory disorders of the intestine.

Place, publisher, year, edition, pages
Wiley-Blackwell Publishing Inc., 2009. Vol. 1165, 220-227 p.
Keyword [en]
epithelium; epithelial barrier; intercellular junctions; tight junctions; ad-herens junctions; desmosomes; inflammation; inflammatory bowel disease; IBD; cytokines
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:liu:diva-141661DOI: 10.1111/j.1749-6632.2009.04025.xISI: 000267364600031PubMedID: 19538310Scopus ID: 2-s2.0-67249099003ISBN: 1749-6632 (Electronic) 0077-8923 (Linking) OAI: oai:DiVA.org:liu-141661DiVA: diva2:1149707
Note

Koch, Stefan Nusrat, Asma eng Review 2009/06/23 09:00 Ann N Y Acad Sci. 2009 May;1165:220-7. doi: 10.1111/j.1749-6632.2009.04025.x.

Available from: 2017-10-16 Created: 2017-10-16 Last updated: 2017-10-25Bibliographically approved

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