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Extrinsic control of Wnt signaling in the intestine
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
2017 (English)In: Differentiation, ISSN 0301-4681, E-ISSN 1432-0436, Vol. 97, p. 1-8Article, review/survey (Refereed) Published
Abstract [en]

The canonical Wnt/beta-catenin signaling pathway is a central regulator of development and tissue homeostasis. In the intestine, Wnt signaling is primarily known as the principal organizer of epithelial stem cell identity and proliferation. Within the last decade, numerous scientific breakthroughs have shed light on epithelial self-organization in the gut, and organoids are now routinely used to study stem cell biology and intestinal pathophysiology. The contribution of non-epithelial cells to Wnt signaling in the gut has received less attention. However, there is mounting evidence that stromal cells are a rich source of Wnt pathway activators and inhibitors, which can dynamically shape Wnt signaling to control epithelial proliferation and restitution. Elucidating the extent and mechanisms of paracrine Wnt signaling in the intestine has the potential to broaden our understanding of epithelial homeostasis, and may be of particular relevance for disorders such as inflammatory bowel diseases and colitis-associated cancers.

Place, publisher, year, edition, pages
Elsevier, 2017. Vol. 97, p. 1-8
Keywords [en]
Cell signaling, Intestinal epithelial cells, Colon, IBD, Colorectal cancer
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:liu:diva-141655DOI: 10.1016/j.diff.2017.08.003ISI: 000417863700001PubMedID: 28802143Scopus ID: 2-s2.0-85026869574ISBN: 1432-0436 (Electronic) 0301-4681 (Linking) OAI: oai:DiVA.org:liu-141655DiVA, id: diva2:1149711
Available from: 2017-10-16 Created: 2017-10-16 Last updated: 2018-01-13Bibliographically approved

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Koch, Stefan

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