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Parkinson's disease-associated receptor GPR37 is an ER chaperone for LRP6
Division of Molecular Embryology, DKFZ‐ZMBH Alliance, Heidelberg, Germany.
Division of Molecular Embryology, DKFZ‐ZMBH Alliance, Heidelberg, Germany.
Division of Molecular Embryology, DKFZ‐ZMBH Alliance, Heidelberg, Germany.
Division of Molecular Embryology, DKFZ‐ZMBH Alliance, Heidelberg, Germany.
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2017 (English)In: EMBO Reports, ISSN 1469-221X, E-ISSN 1469-3178, Vol. 18, no 5, 712-725 p.Article in journal (Refereed) Published
Abstract [en]

Wnt/beta-catenin signaling plays a key role in embryonic development, stem cell biology, and neurogenesis. However, the mechanisms of Wnt signal transmission, notably how the receptors are regulated, remain incompletely understood. Here we describe that the Parkinson's disease-associated receptor GPR37 functions in the maturation of the N-terminal bulky beta-propellers of the Wnt co-receptor LRP6. GPR37 is required for Wnt/beta-catenin signaling and protects LRP6 from ER-associated degradation via CHIP (carboxyl terminus of Hsc70-interacting protein) and the ATPase VCP GPR37 is highly expressed in neural progenitor cells (NPCs) where it is required for Wnt-dependent neurogenesis. We conclude that GPR37 is crucial for cellular protein quality control during Wnt signaling.

Place, publisher, year, edition, pages
Wiley-Blackwell Publishing Inc., 2017. Vol. 18, no 5, 712-725 p.
Keyword [en]
ER-associated degradation; GPR37; LRP6; PAEL-R; Wnt signaling
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:liu:diva-141651DOI: 10.15252/embr.201643585ISI: 000400446100008PubMedID: 28341812Scopus ID: 2-s2.0-85017187389ISBN: 1469-3178 (Electronic) 1469-221X (Linking) OAI: oai:DiVA.org:liu-141651DiVA: diva2:1149715
Note

Berger, Birgit S Acebron, Sergio P Herbst, Jessica Koch, Stefan Niehrs, Christof eng England 2017/03/28 06:00 EMBO Rep. 2017 May;18(5):712-725. doi: 10.15252/embr.201643585. Epub 2017 Mar 24.

Available from: 2017-10-16 Created: 2017-10-16 Last updated: 2017-10-26Bibliographically approved

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