liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
DNA methylation profiles in red blood cells of adult hens correlate with their rearing conditions
Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering. University of Sao Paulo, Brazil. (Avian Behav Genom and Physiol Grp)
Norwegian University of Life Science, Norway.
Norwegian University of Life Science, Norway.
University of Sao Paulo, Brazil.
Show others and affiliations
2017 (English)In: Journal of Experimental Biology, ISSN 0022-0949, E-ISSN 1477-9145, Vol. 220, no 19, p. 3579-3587Article in journal (Refereed) Published
Abstract [en]

Stressful conditions are common in the environment where production animals are reared. Stress in animals is usually determined by the levels of stress-related hormones. A big challenge, however, is in determining the history of exposure of an organism to stress, because the release of stress hormones can show an acute (and recent) but not a sustained exposure to stress. Epigenetic tools provide an alternative option to evaluate past exposure to long-termstress. Chickens provide a unique model to study stress effects in the epigenome of red blood cells (RBCs), a cell type of easy access and nucleated in birds. The present study investigated whether two different rearing conditions in chickens can be identified by looking at DNA methylation patterns in their RBCs later in life. These conditions were rearing in open aviaries versus in cages, which are likely to differ regarding the amount of stress they generate. Our comparison revealed 115 genomic windows with significant changes in RBC DNA methylation between experimental groups, which were located around 53 genes and within 22 intronic regions. Our results set the ground for future detection of long-term stress in live production animals by measuring DNA methylation in a cell type of easy accessibility.

Place, publisher, year, edition, pages
COMPANY OF BIOLOGISTS LTD , 2017. Vol. 220, no 19, p. 3579-3587
Keywords [en]
Erythrocytes; Epigenetics; Chicken; Stress; Animal welfare; Production animals
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:liu:diva-142167DOI: 10.1242/jeb.157891ISI: 000412240500028PubMedID: 28784681OAI: oai:DiVA.org:liu-142167DiVA, id: diva2:1151403
Note

Funding Agencies|Coordenacao de Aperfeicamento de Pessoal de Nivel Superior (CAPES; Brazilian government); Fundaco de Amparo a esquisa do Estado de Sao Paulo (FAPESP) [2016/20440-3]; Foundation for Research Levy on Agricultural Products (FFL); Agricultural Agreement Research Fund; Animalia (Norwegian Meat and Poultry Research Centre) through the Norges Forskningsrad [207739]; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq; Brazilian government); Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP; Sao Paulo State, Brazil) [2014/08704-0]; European Research Council [322206]

Available from: 2017-10-23 Created: 2017-10-23 Last updated: 2018-03-28

Open Access in DiVA

The full text will be freely available from 2018-10-04 15:33
Available from 2018-10-04 15:33

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Jensen, PerGuerrero Bosagna, Carlos
By organisation
BiologyFaculty of Science & Engineering
In the same journal
Journal of Experimental Biology
Neurosciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 108 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf