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CA 19-9 and CA 125 as potential predictors of disease recurrence in resectable lung adenocarcinoma
Lund University, Sweden.
Lund University, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Divison of Neurobiology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Pathology and Clinical Genetics.
Lund University, Sweden.
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2017 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, no 10, e186284Article in journal (Refereed) Published
Abstract [en]

Objectives Among patients who underwent primary surgery for non-small cell lung cancer (NSCLC), recurrent disease is frequent and cannot be accurately predicted solely from TNM stage and histopathological features. The aim of this study was to examine the association of tumor markers in pre-operative serum with recurrent disease. Material and methods Blood samples were collected prior to lung cancer surgery from 107 patients with stage I-III lung adenocarcinoma surgically treated at Lund University hospital, Lund, Sweden, between 2005 and 2011. The serum tumor markers Carcinoembryonic antigen (CEA), Neuron-specific enolase (NSE), Cancer antigen 125 (CA 125), Human epididymis protein 4 (HE4) and Carbohydrate antigen (CA 19-9) were analyzed retrospectively and clinical follow-up data were collected from patient charts. Forty (37%) patients were diagnosed with recurrent disease. Results Sixty-eight (64%) patients had at least one elevated tumor marker prior to surgery. In analysis of disease-free survival (DFS), CA 125 and/or CA 19-9 were significantly associated with recurrent disease adjusted to stage and adjuvant treatment (hazard ratio 2.8, 95% confidence interval 1.4-5.7, p = 0.006). Conclusion High pre-operative serum CA 19-9 and/or CA 125 might indicate an increased incidence of recurrent disease in resectable lung adenocarcinomas.

Place, publisher, year, edition, pages
PUBLIC LIBRARY SCIENCE , 2017. Vol. 12, no 10, e186284
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Gastroenterology and Hepatology
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URN: urn:nbn:se:liu:diva-142835DOI: 10.1371/journal.pone.0186284ISI: 000413195900054PubMedID: 29049328OAI: oai:DiVA.org:liu-142835DiVA: diva2:1154932
Note

Funding Agencies|Swedish Cancer Society; Mrs Berta Kamprad Foundation; Gustav V:s Jubilee Foundation; governmental funding (ALF)

Available from: 2017-11-06 Created: 2017-11-06 Last updated: 2017-12-07

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Monsef, Nastaran
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Divison of NeurobiologyFaculty of Medicine and Health SciencesDepartment of Clinical Pathology and Clinical Genetics
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