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Incidence of bullous pemphigoid in Sweden 2005-2012: a nationwide population-based cohort study of 3761 patients
Karolinska Institute, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences. Regional Joönköping County, Sweden.
Regional Jonköping County, Sweden.
Lund University, Sweden.
2017 (English)In: Archives of Dermatological Research, ISSN 0340-3696, E-ISSN 1432-069X, Vol. 309, no 9, 721-727 p.Article in journal (Refereed) Published
Abstract [en]

Studies that report the incidence of bullous pemphigoid from validated nationwide population-based registries are rare. The aim of this study was to estimate the incidence of bullous pemphigoid in Sweden 2005-2012. A population-based open cohort study was designed including all patients diagnosed by a dermatologist with bullous pemphigoid (BP) in Sweden from 2005 to 2012 (n = 3761), identified from the National Patient Register (NPR). The diagnosis of bullous pemphigoid in the NPR was recently validated from medical records, histopathological and immunopathological data by our group in a previous study. The average annual incidence of bullous pemphigoid was 7.1/100,000 (95% CI 6.5-7.7). Female to male ratio was 1.2:1, mean age at diagnosis was 78.9 years. The age-specific incidence rate increased markedly after 80 years of age with an incidence peak between 90 and 99 years of age, 81.9/100,000 (95% CI 75.0-89.2). This large nationwide cohort study presents an adjusted incidence of BP of 7.1/100,000 (95% CI 6.5-7.7) in Sweden. The incidence of bullous pemphigoid is higher than expected and bullous pemphigoid is a common disease in the elderly population.

Place, publisher, year, edition, pages
SPRINGER , 2017. Vol. 309, no 9, 721-727 p.
Keyword [en]
Incidence; Bullous pemphigoid; Population-based cohort study
National Category
Dermatology and Venereal Diseases
Identifiers
URN: urn:nbn:se:liu:diva-142829DOI: 10.1007/s00403-017-1778-4ISI: 000413313300005PubMedID: 28875235OAI: oai:DiVA.org:liu-142829DiVA: diva2:1154958
Note

Funding Agencies|Karolinska Institutet; Welander-Finsen Foundation; Sigurd and Elsa Goljes Foundation

Available from: 2017-11-06 Created: 2017-11-06 Last updated: 2017-12-07

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