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Auditory display for Fluorescence-guided open brain tumor surgery
Medical Image Computing, University of Bremen; Jacobs University, Bremen; Fraunhofer MEVIS, Bremen, Germany.
Jacobs University, Bremen; Fraunhofer, MEVIS, Germany.
Brigham and Women's Hospital and Harvard Medical School, Boston, USA.
Linköping University, Department of Biomedical Engineering, Division of Biomedical Engineering. Linköping University, Faculty of Science & Engineering. (MINT)ORCID iD: 0000-0002-0012-7867
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2017 (English)In: International Journal of Computer Assisted Radiology and Surgery, ISSN 1861-6410, E-ISSN 1861-6429Article in journal (Refereed) Epub ahead of print
Abstract [en]

PURPOSE:

Protoporphyrin (PpIX) fluorescence allows discrimination of tumor and normal brain tissue during neurosurgery. A handheld fluorescence (HHF) probe can be used for spectroscopic measurement of 5-ALA-induced PpIX to enable objective detection compared to visual evaluation of fluorescence. However, current technology requires that the surgeon either views the measured values on a screen or employs an assistant to verbally relay the values. An auditory feedback system was developed and evaluated for communicating measured fluorescence intensity values directly to the surgeon.

METHODS:

The auditory display was programmed to map the values measured by the HHF probe to the playback of tones that represented three fluorescence intensity ranges and one error signal. Ten persons with no previous knowledge of the application took part in a laboratory evaluation. After a brief training period, participants performed measurements on a tray of 96 wells of liquid fluorescence phantom and verbally stated the perceived measurement values for each well. The latency and accuracy of the participants' verbal responses were recorded. The long-term memorization of sound function was evaluated in a second set of 10 participants 2-3 and 7-12 days after training.

RESULTS:

The participants identified the played tone accurately for 98% of measurements after training. The median response time to verbally identify the played tones was 2 pulses. No correlation was found between the latency and accuracy of the responses, and no significant correlation with the musical proficiency of the participants was observed on the function responses. Responses for the memory test were 100% accurate.

CONCLUSION:

The employed auditory display was shown to be intuitive, easy to learn and remember, fast to recognize, and accurate in providing users with measurements of fluorescence intensity or error signal. The results of this work establish a basis for implementing and further evaluating auditory displays in clinical scenarios involving fluorescence guidance and other areas for which categorized auditory display could be useful.

Place, publisher, year, edition, pages
2017.
Keyword [en]
Fluorescence guided resection, spectroscopy, 5-ALA, PpIX, surgical navigation, neurosurgery, human computer interaction, user interface, sonification, LabVIEW
National Category
Medical Engineering
Identifiers
URN: urn:nbn:se:liu:diva-142857DOI: 10.1007/s11548-017-1667-5OAI: oai:DiVA.org:liu-142857DiVA: diva2:1155089
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Funder
Swedish Childhood Cancer Foundation, MT 2013-0043Linköpings universitet
Available from: 2017-11-06 Created: 2017-11-06 Last updated: 2017-12-11Bibliographically approved

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The full text will be freely available from 2018-09-19 15:06
Available from 2018-09-19 15:06

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Wårdell, KarinHaj Hosseini, Neda
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