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Small molecule detection by lateral flow strips via aptamer-gated silica nanoprobes.
School of Medicine, Istanbul Kemerburgaz University, Istanbul, 34217, Turkey.
Department of Biotechnology, Middle East Technical University, Turkey.
SOMAprobes S.L., Science and Technology Park of Gipuzkoa, San Sebastian 20009, Spain.
SOMAprobes S.L., Science and Technology Park of Gipuzkoa, San Sebastian 20009, Spain.
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2016 (English)In: The Analyst, ISSN 0003-2654, E-ISSN 1364-5528, Vol. 141, no 8, 2595-9 p.Article in journal (Refereed) Published
Abstract [en]

A fast, sensitive and ratiometric biosensor strategy for small molecule detection was developed through nanopore actuation. The new platform engineers together, a highly selective molecular recognition element, aptamers, and a novel signal amplification mechanism, gated nanopores. As a proof of concept, aptamer gated silica nanoparticles have been successfully used as a sensing platform for the detection of ATP concentrations at a wide linear range from 100 μM up to 2 mM.

Place, publisher, year, edition, pages
2016. Vol. 141, no 8, 2595-9 p.
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Chemical Sciences
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URN: urn:nbn:se:liu:diva-142937DOI: 10.1039/c6an00273kPubMedID: 27041474OAI: oai:DiVA.org:liu-142937DiVA: diva2:1156448
Available from: 2017-11-13 Created: 2017-11-13 Last updated: 2017-12-04

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Hernandez, Frank J

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