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Aptámeros: agentes diagnósticos y terapéuticos
University of Iowa, Iowa City, USA.
Estudiante de Microbiología y Bioanálisis, Escuela de Microbiología, Universidad de Antioquia, Medellín, Colombia..
2012 (English)In: Iatreia, ISSN 0121-0793, E-ISSN 2011-7965, Vol. 25, p. 159-168Article in journal (Refereed) Published
Abstract [en]

Aptamers are single-stranded DNA or RNA molecules that recognize a variety of target molecules with high levels of affinity and specificity, due to their particular three-dimensional structure. They are similar to antibodies regarding the recognition process. However, they offer significant advantages over antibodies based on their size, ease of production and various chemical modifications. Thus, they are excellent candidates for developing new biotechnological platforms. Up to date, several aptamers with therapeutic properties have been successfully evaluated in animal models and clinical trials. Moreover, one of them has already been approved by the FDA. Advances during the last two decades allow to foresee that aptamers will play a key role as diagnostic and therapeutic agents in the near future.

Place, publisher, year, edition, pages
scielo , 2012. Vol. 25, p. 159-168
Keywords [en]
Biological Markers, Biomedical Research, Biological Therapy, Clinical Diagnostic, Clinical Medicine, Nucleic Acids, Therepeutical Approaches.
National Category
Medical Biotechnology
Identifiers
URN: urn:nbn:se:liu:diva-142953OAI: oai:DiVA.org:liu-142953DiVA, id: diva2:1156470
Available from: 2017-11-13 Created: 2017-11-13 Last updated: 2017-12-04

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Hernandez, Frank J.
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CiteExportLink to record
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Citation style
  • apa
  • harvard1
  • ieee
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More styles
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