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Microbiota in Functional Gastrointestinal Disorders in Infancy: Implications for Management
Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Linköping.
University of Toronto, Canada.
University of Toronto, Canada.
2017 (English)In: INTESTINAL MICROBIOME: FUNCTIONAL ASPECTS IN HEALTH AND DISEASE, KARGER , 2017, Vol. 88, p. 107-115Conference paper, Published paper (Refereed)
Abstract [en]

The complex and diverse intestinal microbiome is recognized as important in promoting human health. An altered gut microflora, referred to as dysbiosis, is increasingly recognized as having an etiologic role in a variety of conditions, including functional gastrointestinal disorders: colic in infants and irritable bowel syndrome in older children. Probiotics are defined as live microorganisms that, if ingested in sufficient amounts, restore microbial homeostasis and have a benefit on health. Randomized controlled trials indicate that probiotics can be effective in a variety of intestinal conditions, including colic and irritable bowel syndrome. Probiotics may promote gut microbial diversity, but timing of the intervention appears crucial. Strain-specific effects on colonization resistance, epithelial barrier integrity, modulation of signal transduction, impacts on innate and adaptive immune responses, and effects on visceral hyperalgesia likely explain the observed variability in various probiotic strains. In the future, probiotics are likely to be chosen for use in a defined clinical setting based on underlying mechanism(s) of action. The precise component of the probiotic agent mediating observed effects is the subject of current research. Unresolved issues relate to optimal dosages, timing of ingestion, single versus combination formulations, maintenance of viability in storage, and the merits of employing probiotic- derived products. (C) 2017 Nestec Ltd., Vevey/S. Karger AG, Basel

Place, publisher, year, edition, pages
KARGER , 2017. Vol. 88, p. 107-115
Series
Nestle Nutrition Institute Workshop Series, ISSN 1664-2147
National Category
Pediatrics
Identifiers
URN: urn:nbn:se:liu:diva-143004DOI: 10.1159/000455219ISI: 000413698400011PubMedID: 28346927ISBN: 978-3-318-06031-7 (electronic)ISBN: 978-3-318-06030-0 (print)OAI: oai:DiVA.org:liu-143004DiVA, id: diva2:1156517
Conference
88th Nestle-Nutrition-Institute Workshop on Intestinal Microbiome - Functional Aspects in Health and Disease
Note

Funding Agencies|Swedish Society for Medical Research; Canadian Institutes of Health Research (CIHR); Vanier Graduate Scholarship Award from the CIHR; Canada Research Chair in Gastrointestinal Disease

Available from: 2017-11-13 Created: 2017-11-13 Last updated: 2017-11-13

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Division of Children's and Women's healthFaculty of Medicine and Health SciencesDepartment of Paediatrics in Linköping
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