Understanding how the brain works represents probably the most important fundamental endeavor of humankind and holds the key for the development of new technologies that can help improve the lives of people suffering from neurological conditions such as epilepsy and Parkinson's disease. Over the past decade, the use of organic electronic devices to interface with the biological world has received a great deal of attention and bloomed into a field now called “organic bioelectronics”. One of the key differences of organic from traditional electronic materials is their capacity to exchange ions with electrolytes. We discuss how this property can be leveraged to design new types of devices that interface with the brain.Read