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Increased prevalence of celiac disease in idiopathic inflammatory myopathies
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
University Hospital Örebro, Sweden.
Linköping University, Department of Social and Welfare Studies, Division of Health, Activity and Care. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in East Östergötland, Department of Internal Medicine in Norrköping.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in Central Östergötland, Department of Neurology.
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2017 (English)In: Brain and Behavior, ISSN 2162-3279, E-ISSN 2162-3279, Vol. 7, no 10, e00803Article in journal (Refereed) Published
Abstract [en]

ObjectivesIdiopathic inflammatory myopathies (IIM) are often associated with other immune-mediated diseases or malignancy. Some studies have reported a high frequency of celiac disease in IIM. The aim of this study was to investigate the prevalence of celiac disease, systemic inflammatory diseases, and malignancy in a cohort of IIM patients, and estimate the incidence of IIM in the county of ostergotland, Sweden. Material and MethodsWe reviewed medical records and analyzed sera from 106 patients, fulfilling pathological criteria of inflammatory myopathy, for the presence of IgA antibodies against endomysium and gliadin. Antibody-positive patients were offered further investigation with small bowel biopsy or investigation for the presence of antibodies against antitissue transglutaminase (t-TG). The patients were classified according to Bohan and Peter or Griggs criteria. The presence of celiac disease, systemic inflammatory, and malignant diseases was documented. ResultsFour of 88 patients classified as IIM (4.5%) had biopsy-confirmed celiac disease, which is higher than the prevalence in the general population, detected with a similar screening procedure (0.53%). Thirty-three patients (38%) had a systemic inflammatory disease and five (5.7%) a malignancy. The incidence of confirmed IIM in the county of ostergotland was 7.3 per million/year. ConclusionsThe results highlight the high frequency of associated inflammatory and malignant diseases and confirm an increased prevalence of celiac disease in IIM.

Place, publisher, year, edition, pages
WILEY , 2017. Vol. 7, no 10, e00803
Keyword [en]
celiac disease; idiopathic inflammatory myopathies; incidence; myositis; prevalence
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Neurology
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URN: urn:nbn:se:liu:diva-143101DOI: 10.1002/brb3.803ISI: 000413532400010PubMedID: 29075563OAI: oai:DiVA.org:liu-143101DiVA: diva2:1159391
Note

Funding Agencies|Linkoping University; Region Ostergotland

Available from: 2017-11-22 Created: 2017-11-22 Last updated: 2017-11-22

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Danielsson, OlofHallert, ClaesVrethem, MagnusDahle, Charlotte
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Division of Neuro and Inflammation ScienceFaculty of Medicine and Health SciencesDivision of Health, Activity and CareDepartment of Internal Medicine in NorrköpingDepartment of NeurologyDepartment of Clinical Immunology and Transfusion Medicine
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