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Do patients with Menieres disease have attacks of syncope?
University of Tampere, Finland.
Linköping University, Department of Behavioural Sciences and Learning, Disability Research. Linköping University, Faculty of Arts and Sciences. Linköping University, The Swedish Institute for Disability Research. Lamar University, TX 77710 USA; Audiol India, India; Manipal University, India.
University of Tampere, Finland; Second Mil Medical University, Peoples R China.
University of Helsinki, Finland.
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2017 (English)In: Journal of Neurology, ISSN 0340-5354, E-ISSN 1432-1459, Vol. 264, S48-S54 p.Article in journal (Refereed) Published
Abstract [en]

The aim of the present study was to evaluate the prevalence and associated factors for syncope among patients with Menieres disease (MD). An attack of syncope was defined as a sudden and transient loss of consciousness, which subsides spontaneously and without a localizing neurological deficit. The study used an across-sectional survey design. Information from a database consisting of 961 individuals was collected from the Finnish Meniere Association. The data contained case histories, general health-related quality of life (HRQoL), and impact measurements of the complaints. In the current study sample, syncope occurred in 12.3% of the patients with MD. It was more prevalent among elderly persons and among those with a longer duration of MD. Syncope was significantly associated with disturbances of otolith function reflected as Tumarkin attacks, gait and balance problems, environmental change of pressure, and physical strain. It was also associated with visual blurring; in fact, patients with otolith dysfunction in MD often experience visual field changes. It was also associated with headache, but not with migraine. Syncope was experienced as frightening and HRQoL was significantly worsened. The patient had higher anxiety scores, and suffered more from fatigue. The results demonstrate that neurally mediated syncope occurs in patients with an advanced form of MD who suffer from Tumarkin attacks due to failure in otolith function. The mechanism seems to be triggered through the vestibular sympathetic reflex when the otolith system fails due to disrupted utricular otolithic membrane mediate erroneous positional information from the otolith organ to the vasomotor centres in the brain stem and medulla.

Place, publisher, year, edition, pages
SPRINGER HEIDELBERG , 2017. Vol. 264, S48-S54 p.
Keyword [en]
Menieres disease; Tumarkin attacks; Drop attack; Fainting vestibular disorder; Otolith organ; Syncope
National Category
Neurology
Identifiers
URN: urn:nbn:se:liu:diva-143100DOI: 10.1007/s00415-017-8452-9ISI: 000413762000014PubMedID: 28321563OAI: oai:DiVA.org:liu-143100DiVA: diva2:1159395
Note

Funding Agencies|German Federal Ministry of Education and Research

Available from: 2017-11-22 Created: 2017-11-22 Last updated: 2017-11-22

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