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Rotavirus infection
Baylor Coll Med, TX 77030 USA.
Baylor Coll Med, TX 77030 USA.
US Centre Disease Control and Prevent, GA USA.
US Centre Disease Control and Prevent, GA USA.
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2017 (English)In: NATURE REVIEWS DISEASE PRIMERS, ISSN 2056-676X, Vol. 3, 17083Article in journal (Refereed) Published
Abstract [en]

Rotavirus infections are a leading cause of severe, dehydrating gastroenteritis in children amp;lt;5 years of age. Despite the global introduction of vaccinations for rotavirus over a decade ago, rotavirus infections still result in amp;gt;200,000 deaths annually, mostly in low-income countries. Rotavirus primarily infects enterocytes and induces diarrhoea through the destruction of absorptive enterocytes (leading to malabsorption), intestinal secretion stimulated by rotavirus non-structural protein 4 and activation of the enteric nervous system. In addition, rotavirus infections can lead to antigenaemia (which is associated with more severe manifestations of acute gastroenteritis) and viraemia, and rotavirus can replicate in systemic sites, although this is limited. Reinfections with rotavirus are common throughout life, although the disease severity is reduced with repeat infections. The immune correlates of protection against rotavirus reinfection and recovery from infection are poorly understood, although rotavirus-specific immunoglobulin A has a role in both aspects. The management of rotavirus infection focuses on the prevention and treatment of dehydration, although the use of antiviral and anti-emetic drugs can be indicated in some cases.

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP , 2017. Vol. 3, 17083
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:liu:diva-143070DOI: 10.1038/nrdp.2017.83ISI: 000414774300001PubMedID: 29119972OAI: oai:DiVA.org:liu-143070DiVA: diva2:1159453
Available from: 2017-11-22 Created: 2017-11-22 Last updated: 2017-11-22

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Svensson, LennartHagbom, Marie
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Division of Microbiology and Molecular MedicineFaculty of Medicine and Health Sciences
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