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Downregulation of tumor suppressive microRNAs in vivo in dense breast tissue of postmenopausal women
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Oncology.
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Oncology.
Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Radiology in Linköping.
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Oncology.
2017 (English)In: OncoTarget, ISSN 1949-2553, E-ISSN 1949-2553, Vol. 8, no 54, 92134-92142 p.Article in journal (Refereed) Published
Abstract [en]

Women with dense breast tissue on mammography are at higher risk of developing breast cancer but the underlying mechanisms are not well understood. De-regulation of microRNAs (miRNAs) has been associated with the onset of breast cancer. miRNAs in the extracellular space participate in the regulation of the local tissue microenvironment. Here, we recruited 39 healthy postmenopausal women attending their mammography-screen that were assessed having extreme dense or entirely fatty breasts (nondense). Microdialysis was performed in breast tissue and a reference catheter was inserted in abdominal subcutaneous fat for local sampling of extracellular compounds. Three miRNAs, associated with tumor suppression, miR-193b, miR-365a, and miR-452 were significantly down-regulated in dense breast tissue compared with nondense breast tissue. In addition, miR-452 exhibited significant negative correlations with several pro-inflammatory cytokines in vivo, which was confirmed in vitro by overexpression of miR-452 in breast cancer cells. No differences were found of miR-21, -29a, -30c, 146a, -148a, -203, or -451 in breast tissue and no miRs were different in plasma. Extracellular miRNAs may be among factors that should be included in studies of novel prevention strategies for breast cancer.

Place, publisher, year, edition, pages
Impact Journals LCC , 2017. Vol. 8, no 54, 92134-92142 p.
Keyword [en]
mammary gland; microdialysis; mammography; extracellular miRNA; inflammation
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:liu:diva-143240DOI: 10.18632/oncotarget.20906ISI: 000414606800026PubMedID: 29190903Scopus ID: 2-s2.0-85032692532OAI: oai:DiVA.org:liu-143240DiVA: diva2:1160444
Note

Funding Agencies|Swedish Cancer Society [2015/309]; Swedish Research Council [2013-2457]; LiU-Cancer; ALF of Linkoping University Hospital

Available from: 2017-11-27 Created: 2017-11-27 Last updated: 2017-12-06Bibliographically approved

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Capodanno, Alessandra

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Abrahamsson, AnnelieCapodanno, AlessandraRzepecka, AnnaDabrosin, Charlotta
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Division of Surgery, Orthopedics and OncologyFaculty of Medicine and Health SciencesDepartment of OncologyDepartment of Medical and Health SciencesDepartment of Radiology in Linköping
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