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Aptamers as a model for functional evaluation of LNA and 2′-amino LNA
Nucleic Acid Center, Biochemistry and Molecular Biology Department, University of of Southern Denmark, Campusvej 55, Odense M, 5230, Denmark.
Department of Physics and Chemistry, University of of Southern Denmark, Campusvej 55, Odense M, 5230, Denmark.
Department of Physics and Chemistry, University of of Southern Denmark, Campusvej 55, Odense M, 5230, Denmark.
Nucleic Acid Center, Biochemistry and Molecular Biology Department, University of of Southern Denmark, Campusvej 55, Odense M, 5230, Denmark.
2009 (English)In: Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, E-ISSN 1090-2120, Vol. 19, no 23, 6585-6587 p.Article in journal (Refereed) Published
Abstract [en]

The affinity change upon incorporation of LNA and 2′-amino-LNA monomers into an avidin binding DNA aptamer is described. The kinetic profile of selected modified-aptamer was obtained by surface plasmon resonance experiments and compared with the profile of the parent unmodified DNA aptamer. We report significant improvement of avidin binding affinity by the incorporation of single LNA modifications into the aptamer, and successful incorporation of 2′-amino LNA as a novel monomer in aptamers with potential function as carrier unit for additional molecular entities. © 2009 Elsevier Ltd. All rights reserved.

Place, publisher, year, edition, pages
Pergamon Press, 2009. Vol. 19, no 23, 6585-6587 p.
Keyword [en]
2′-Amino-LNA; Affinity; Aptamer; LNA; Surface plasmon resonance
National Category
Other Basic Medicine
Identifiers
URN: urn:nbn:se:liu:diva-143342DOI: 10.1016/j.bmcl.2009.10.039ISI: 000271430400019PubMedID: 19864131Scopus ID: 2-s2.0-71749097854OAI: oai:DiVA.org:liu-143342DiVA: diva2:1162513
Available from: 2017-12-04 Created: 2017-12-04 Last updated: 2017-12-13Bibliographically approved

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Hernandez, Frank J

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