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Targeting cancer cells with controlled release nanocapsules based on a single aptamer
Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of of Iowa, Iowa City, IA 52242, United States.
Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of of Iowa, Iowa City, IA 52242, United States.
NanoBioSeparations Group, POLYMAT, University of of the Basque Country UPV/EHU, Avda. Tolosa 72, Donostia-San-Sebastián, Spain.
NanoBioSeparations Group, POLYMAT, University of of the Basque Country UPV/EHU, Avda. Tolosa 72, Donostia-San-Sebastián, Spain; Ikerbasque, Basque Foundation for Science, 48011 Bilbao, Spain.
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2013 (English)In: Chemical Communications, ISSN 1359-7345, E-ISSN 1364-548X, Vol. 49, no 13, 1285-1287 p.Article in journal (Refereed) Published
Abstract [en]

Molecular gates have received considerable attention as drug delivery systems. More recently, aptamer-based gates showed great potential in overcoming major challenges associated with drug delivery by means of nanocapsules. Based on a switchable aptamer nanovalves approach, we herein report the first demonstration of an engineered single molecular gate that directs nanoparticles to cancer cells and subsequently delivers the payload in a controllable fashion. © 2012 The Royal Society of Chemistry.

Place, publisher, year, edition, pages
Royal Society of Chemistry, 2013. Vol. 49, no 13, 1285-1287 p.
National Category
Pharmaceutical Sciences
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URN: urn:nbn:se:liu:diva-143336DOI: 10.1039/c2cc37370jISI: 000313663900010PubMedID: 23295617Scopus ID: 2-s2.0-84872583189OAI: oai:DiVA.org:liu-143336DiVA: diva2:1162519
Available from: 2017-12-04 Created: 2017-12-04 Last updated: 2017-12-13Bibliographically approved

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Hernandez, Frank JHernandez, Luiza I.

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