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Structural advances on titin: towards an atomic understanding of multi-domain functions in myofilament mechanics and scaffolding.
Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom.
Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom, Netherlands Cancer Institute, Amsterdam, Netherlands.
Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom.
Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom.
2015 (English)In: Biochemical Society Transactions, ISSN 0300-5127, E-ISSN 1470-8752, Vol. 43, no 5, p. 850-5Article in journal (Refereed) Published
Abstract [en]

Titin is a gigantic filamentous protein of the muscle sarcomere that plays roles in myofibril mechanics and homoeostasis. 3D-structures of multi-domain fragments of titin are now available that start revealing the molecular mechanisms governing its mechanical and scaffolding functions. This knowledge is now being translated into the fabrication of self-assembling biopolymers. Here we review the structural advances on titin, the novel concepts derived from these and the emerging translational avenues.

Place, publisher, year, edition, pages
Portland Press Ltd , 2015. Vol. 43, no 5, p. 850-5
Keywords [en]
crystal structure, multi-Ig tandem, protein nanofibre, protein scaffold, titin
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:liu:diva-143659DOI: 10.1042/BST20150084PubMedID: 26517893OAI: oai:DiVA.org:liu-143659DiVA, id: diva2:1165094
Available from: 2017-12-12 Created: 2017-12-12 Last updated: 2017-12-12

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von Castelmur, Eleonore
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