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Genetic and environmental aspects in the association between attention-deficit hyperactivity disorder symptoms and binge-eating behavior in adults: a twin study
Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in Central Östergötland, Department of Psychiatry.
Karolinska Institute, Sweden.
Karolinska Institute, Sweden.
Karolinska Institute, Sweden; University of North Carolina Chapel Hill, NC USA; University of North Carolina Chapel Hill, NC USA.
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2017 (English)In: Psychological Medicine, ISSN 0033-2917, E-ISSN 1469-8978, Vol. 47, no 16, p. 2866-2878Article in journal (Refereed) Published
Abstract [en]

Background Prior research demonstrated that attention-deficit hyperactivity disorder (ADHD) is associated with binge-eating behavior, binge-eating disorder (BED), and bulimia nervosa (BN). The aim of this study was to investigate these associations in an adult twin population, and to determine the extent to which ADHD symptoms and binge-eating behavior share genetic and environmental factors. Methods We used self-reports of current ADHD symptoms and lifetime binge-eating behavior and associated characteristics from a sample of over 18 000 adult twins aged 20-46 years, from the population-based Swedish Twin Registry. Mixed-effects logistic regression was used to examine the association between ADHD and lifetime binge-eating behavior, BED, and BN. Structural equation modeling was used in 13 773 female twins to determine the relative contribution of genetic and environmental factors to the association between ADHD symptoms and binge-eating behavior in female adult twins. Results ADHD symptoms were significantly associated with lifetime binge-eating behavior, BED, and BN. The heritability estimate for current ADHD symptoms was 0.42 [95% confidence interval (CI) 0.41-0.44], and for lifetime binge-eating behavior 0.65 (95% CI 0.54-0.74). The genetic correlation was estimated as 0.35 (95% CI 0.25-0.46) and the covariance between ADHD and binge-eating behavior was primarily explained by genetic factors (91%). Non-shared environmental factors explained the remaining part of the covariance. Conclusions The association between adult ADHD symptoms and binge-eating behavior in females is largely explained by shared genetic risk factors.

Place, publisher, year, edition, pages
CAMBRIDGE UNIV PRESS , 2017. Vol. 47, no 16, p. 2866-2878
Keyword [en]
ADHD; binge eating; bivariate twin analysis; heritability; twins
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:liu:diva-143626DOI: 10.1017/S0033291717001416ISI: 000416044800012PubMedID: 28578734OAI: oai:DiVA.org:liu-143626DiVA, id: diva2:1165580
Note

Funding Agencies|ALF Grants, Region Ostergotland, Sweden [LIO-440851]; Swedish Research Council (VR) [Dnr: 538-2013-8864]; China Scholarship Council

Available from: 2017-12-13 Created: 2017-12-13 Last updated: 2017-12-13

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Johansson Capusan, AndreaBendtsen, PrebenMarteinsdottir, InaThorsell, Annika
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Division of Community MedicineFaculty of Medicine and Health SciencesDepartment of PsychiatryDepartment of Medical Specialist in MotalaCenter for Social and Affective Neuroscience
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