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Exploring the multifaceted nature of the common lymphoidprogenitor compartment
Lund Univ, Div Mol Hematol, S-22100 Lund, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Lund Univ, Div Mol Hematol, S-22100 Lund, Sweden.
2016 (English)In: Current Opinion in Immunology, ISSN 0952-7915, E-ISSN 1879-0372, Vol. 39, p. 121-126Article, review/survey (Refereed) Published
Abstract [en]

While the common lymphoid progenitor compartment was originally thought to be a rather homogenous cell population, it has become increasingly clear that this compartment is highly heterogeneous both with regard to phenotypic and functional features. The exploration of this cellular complexity has generated novel molecular insights into regulatory events in lymphoid lineage restriction and provided support for the idea that multiple lineage restriction events occur at this developmental stage. Furthermore, the identification of multiple lineage-restricted progenitors with mixed lineage potential challenges a strictly hierarchical model for lymphoid development. Instead we propose a model based on competence windows during which cell fates are established through the action of lineage determining factors.

Place, publisher, year, edition, pages
Current Biology ltd , 2016. Vol. 39, p. 121-126
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-143797DOI: 10.1016/j.coi.2016.01.009ISI: 000373866000019OAI: oai:DiVA.org:liu-143797DiVA, id: diva2:1167393
Note

Funding agencies:This work was supported by grants from The Swedish Cancer Society, The Swedish Research Council, Knut and Alice Wallenberg Foundation, The Swedish Childhood Cancer Foundation, and a donation from Henry Hallberg.

Available from: 2017-12-18 Created: 2017-12-18 Last updated: 2017-12-18

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