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Whole-body adipose tissue and lean muscle volumes and their distribution across gender and age: MR-derived normative values in a normal-weight Swiss population
University Hospital, Switzerland; University of Zurich, Switzerland.
University Hospital, Switzerland; University of Zurich, Switzerland.
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics. Linköping University, Center for Medical Image Science and Visualization (CMIV). Adv MR Analyt AB, Linkoping, Sweden.
University Hospital, Switzerland; University of Zurich, Switzerland.
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2018 (English)In: Magnetic Resonance in Medicine, ISSN 0740-3194, E-ISSN 1522-2594, Vol. 79, no 1, p. 449-458Article in journal (Refereed) Published
Abstract [en]

PurposeTo determine age- and gender-dependent whole-body adipose tissue and muscle volumes in healthy Swiss volunteers in Dixon MRI in comparison with anthropometric and bioelectrical impedance (BIA) measurements. MethodsFat-water-separated whole-body 3 Tesla MRI of 80 healthy volunteers (ages 20 to 62 years) with a body mass index (BMI) of 17.5 to 26.2kg/m(2) (10 men, 10 women per decade). Age and gender-dependent volumes of total adipose tissue (TAT), visceral adipose tissue (VAT), total abdominal subcutaneous adipose tissue (ASAT) and total abdominal adipose tissue (TAAT), and the total lean muscle tissue (TLMT) normalized for body height were determined by semi-automatic segmentation, and correlated with anthropometric and BIA measurements as well as lifestyle parameters. ResultsThe TAT, ASAT, VAT, and TLMT indexes (TATi, ASATi, VATi, and TLMTi, respectively) (L/m(2)standard deviation) for women/men were 6.4 +/- 1.8/5.3 +/- 1.7, 1.6 +/- 0.7/1.2 +/- 0.5, 0.4 +/- 0.2/0.8 +/- 0.5, and 5.6 +/- 0.6/7.1 +/- 0.7, respectively. The TATi correlated strongly with ASATi (ramp;gt;0.93), VATi, BMI and BIA (ramp;gt;0.70), and TAATi (ramp;gt;0.96), and weak with TLMTi for both genders (ramp;gt;-0.34). The VAT was the only parameter showing an age dependency (ramp;gt;0.32). The BMI and BIA showed strong correlation with all MR-derived adipose tissue volumes. The TAT mass was estimated significantly lower from BIA than from MRI (both genders Pamp;lt;.001; mean bias -5kg). ConclusionsThe reported gender-specific MRI-based adipose tissue and muscle volumes might serve as normative values. The estimation of adipose tissue volumes was significantly lower from anthropometric and BIA measurements than from MRI. Magn Reson Med 79:449-458, 2018. (c) 2017 International Society for Magnetic Resonance in Medicine.

Place, publisher, year, edition, pages
WILEY , 2018. Vol. 79, no 1, p. 449-458
Keyword [en]
total adipose tissue (TAT); lean skeletal muscle tissue (LMT); fat-water-separated MRI; Dixon; age and sex-dependent normative values; whole-body fat
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:liu:diva-143886DOI: 10.1002/mrm.26676ISI: 000417926300044PubMedID: 28432747OAI: oai:DiVA.org:liu-143886DiVA: diva2:1170087
Note

Funding Agencies|University Zurich Research Program "Research Time for Clinical Research at the Medical Faculty of University Zurich" [RT-13-014]

Available from: 2018-01-02 Created: 2018-01-02 Last updated: 2018-01-02

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Dahlqvist Leinhard, Olof
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Division of Radiological SciencesFaculty of Medicine and Health SciencesDepartment of Radiation PhysicsCenter for Medical Image Science and Visualization (CMIV)
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