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Pregnancy modulates the allergen-induced cytokine production differently in allergic and non-allergic women
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Immunology and Transfusion Medicine.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
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2017 (English)In: Pediatric Allergy and Immunology, ISSN 0905-6157, E-ISSN 1399-3038, Vol. 28, no 8, p. 818-824Article in journal (Refereed) Published
Abstract [en]

Background: The immunological environment during pregnancy may differ between allergic and non-allergic women. This study investigates the effect of maternal allergy on the allergen-induced cytokine and chemokine levels and whether pregnancy modulates these immune responses differently in allergic and non-allergic women. Methods: The birch-, cat-, phytohemagglutinin- and tetanus toxoid-induced interferon-gamma(IFN-gamma), interleukin (IL)-4, IL-5, IL-10, IL-13, the T-helper 1 (Th1)-associated chemokine CXCL10 and the Th2-associated chemokine CCL17 levels were quantified in 20 women with allergic symptoms (sensitized, n=13) and 36 women without allergic symptoms (non-sensitized, n=30) at gestational weeks 10-12, 15-16, 25, 35 and 2 and 12months post-partum. Results: Birch-, but not cat-induced, IL-5, IL-13 and CCL17 levels were increased during pregnancy as compared to post-partum in the sensitized women with allergic symptoms. In contrast, cat-, but not birch-induced, IL-5 and IL-13 levels were increased during pregnancy as compared to post-partum in the non-sensitized women without allergic symptoms. Furthermore, IFN-gamma secretion was increased in the first and decreased in the second and third trimesters in response to birch and decreased in the third trimester in response to cat as compared to post-partum in the non-sensitized women without allergic symptoms. Increased allergen-induced IL-4, IL-5 and IL-13 levels were associated with allergic symptoms and sensitization. Conclusions: Pregnancy had a clear effect on the allergen-induced IL-5, IL-13, CCL17, IFN-gamma and CXCL10 production, with distinct enhanced Th2-responses to birch in the allergic group and to cat in the non-allergic group.

Place, publisher, year, edition, pages
WILEY , 2017. Vol. 28, no 8, p. 818-824
Keywords [en]
allergy; birch; cat; chemokines; cytokines; immune regulation; pregnancy; rhinitis; T cells
National Category
Respiratory Medicine and Allergy
Identifiers
URN: urn:nbn:se:liu:diva-144152DOI: 10.1111/pai.12802ISI: 000418439700012PubMedID: 28892576OAI: oai:DiVA.org:liu-144152DiVA, id: diva2:1172281
Note

Funding Agencies|Swedish Research Council [73X-15335-01A, 74X-20146-01-2]; National Swedish Association against Allergic Diseases; National Heart and Lung Association; Vardal Foundation for Health Care Sciences and Allergy Research; Olle Engkvist Foundation; Cancer and Allergy Association; Samariten Foundation; Queen Silvia research foundation; Ellen, Walter and Lennart Hesselmans foundation; County Council of Ostergotland

Available from: 2018-01-09 Created: 2018-01-09 Last updated: 2018-02-01

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The full text will be freely available from 2018-10-03 12:41
Available from 2018-10-03 12:41

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Abelius, MartinaJedenfalk, MalinErnerudh, JanJanefjord, CamillaBerg, GöranMatthiesen, LeifJenmalm, Maria
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Division of Neuro and Inflammation ScienceFaculty of Medicine and Health SciencesDepartment of Clinical Immunology and Transfusion MedicineDivision of Children's and Women's healthDepartment of Gynaecology and Obstetrics in Linköping
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Pediatric Allergy and Immunology
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