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Diabetic nephropathy in type 1 diabetes
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Endocrinology. National and Kapodistrian University of Athens, Aghia Sophia Children's Hospital, Athens, Greece..
National and Kapodistrian University of Athens, Aghia Sophia Children's Hospital, Athens, Greece...
Department of Internal Medicine, Medical Center of Athens, Athens, Greece..
Department of Internal Medicine, Medical Center of Athens, Athens, Greece.
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2018 (English)In: Minerva Medica, ISSN 0026-4806, E-ISSN 1827-1669, Vol. 9, no 3, p. 218-228Article, review/survey (Refereed) Published
Abstract [en]

Diabetic nephropathy (DN) also named diabetic kidney disease (DN) is one of the leading causes of mortality in people with diabetes. The aim of this review is to update the medical literature, the theories behind its early natural history, the pathways of its pathogenesis, its diagnosis and treatment. Poor glycemic control, hyperlipidemia, smoking, oxidative stress, accumulation of advanced glycated end products, environmental, genetic and epigenetic factors play an important role in the pathophysiological development of DN. Microalbuminuria has been traditionally used as the primary early diagnostic marker of microvascular complication unraveling the risk for progress to severe cardiorenal outcomes, but its prognostic role has been recently debated. The disease often leads to end-stage renal disease and it is often associated with major cardiovascular outcomes. Its early diagnosis is crucial for the patients in order to have a chance for proper treatment.

Place, publisher, year, edition, pages
Turin, Italy: Edizioni Minerva Medica , 2018. Vol. 9, no 3, p. 218-228
Keywords [en]
Diabetic nephropathy, Complications, Diabetes
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:liu:diva-144191DOI: 10.23736/S0026-4806.17.05496-9ISI: 000445232800004PubMedID: 29205998OAI: oai:DiVA.org:liu-144191DiVA, id: diva2:1172298
Available from: 2018-01-09 Created: 2018-01-09 Last updated: 2019-05-03Bibliographically approved

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Papadopoulou-Marketou, Nektaria

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Division of Cardiovascular MedicineFaculty of Medicine and Health SciencesDepartment of Endocrinology
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