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Comparing Methods for Estimating Direct Costs of Adverse Drug Events
Nordic School Public Health NHV, Sweden; University of Gothenburg, Sweden; Karolinska Institute, Sweden.
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Pharmacology.
Nordic School Public Health NHV, Sweden; EPID Research, Finland.
Narhalsan Hjallbo Medical Centre, Finland.
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2017 (English)In: Value in Health, ISSN 1098-3015, E-ISSN 1524-4733, Vol. 20, no 10, p. 1299-1310Article in journal (Refereed) Published
Abstract [en]

Objectives: To estimate how direct health care costs resulting from adverse drug events (ADEs) and cost distribution are affected by methodological decisions regarding identification of ADEs, assigning relevant resource use to ADEs, and estimating costs for the assigned resources. Methods: ADEs were identified from medical records and diagnostic codes for a random sample of 4970 Swedish adults during a 3-month study period in 2008 and were assessed for causality. Results were compared for five cost evaluation methods, including different methods for identifying ADEs, assigning resource use to ADEs, and for estimating costs for the assigned resources (resource use method, proportion of registered cost method, unit cost method, diagnostic code method, and main diagnosis method). Different levels of causality for ADEs and ADEs contribution to health care resource use were considered. Results: Using the five methods, the maximum estimated overall direct health care costs resulting from ADEs ranged from Sk10,000 (Sk = Swedish krona; similar to(sic)1,500 in 2016 values) using the diagnostic code method to more than Sk3,000,000 (similar to(sic)414,000) using the unit cost method in our study population. The most conservative definitions for ADEs contribution to health care resource use and the causality of ADEs resulted in average costs per patient ranging from Sk0 using the diagnostic code method to Sk4066 (similar to(sic)500) using the unit cost method. Conclusions: The estimated costs resulting from ADEs varied considerably depending on the methodological choices. The results indicate that costs for ADEs need to be identified through medical record review and by using detailed unit cost data. Copyright (C) 2017, International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE INC , 2017. Vol. 20, no 10, p. 1299-1310
Keyword [en]
adverse drug event; health care costs; medical records; pharmacoeconomics
National Category
Health Care Service and Management, Health Policy and Services and Health Economy
Identifiers
URN: urn:nbn:se:liu:diva-144456DOI: 10.1016/j.jval.2017.06.007ISI: 000419245600009PubMedID: 29241889OAI: oai:DiVA.org:liu-144456DiVA, id: diva2:1176569
Note

Funding Agencies|National Corporation of Swedish Pharmacies (Apoteket AB); Region Vastra Gotaland; Ostergotland County Council

Available from: 2018-01-22 Created: 2018-01-22 Last updated: 2018-01-22

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Jönsson, Anna KHägg, Staffan
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Division of Drug ResearchFaculty of Medicine and Health SciencesDepartment of Clinical Pharmacology
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