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Oxidant-induced autophagy and ferritin degradation contribute to epithelial-mesenchymal transition through lysosomal iron
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Respiratory Medicine.
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences.
Division of Medicine, Ryhov Hospital, Jönköping, Sweden.
Division of Medicine, Hospital of Eksjö, Eksjö, Sweden.
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2017 (English)In: Journal of Inflammation Research, ISSN 1178-7031, E-ISSN 1178-7031, Vol. 10, p. 29-39Article in journal (Refereed) Published
Abstract [en]

Transforming growth factor (TGF)-ß1 triggers epithelial-mesenchymal transition (EMT) through autophagy, which is partly driven by reactive oxygen species (ROS). The aim of this study was to determine whether leaking lysosomes and enhanced degradation of H-ferritin could be involved in EMT and whether it could be possible to prevent EMT by iron chelation targeting of the lysosome.

Place, publisher, year, edition, pages
Dove Medical Press , 2017. Vol. 10, p. 29-39
Keywords [en]
A549 cells; COPD; pulmonary disease; pulmonary fibrosis; transforming growth factor; tumor necrosis factor
National Category
Immunology
Identifiers
URN: urn:nbn:se:liu:diva-145062DOI: 10.2147/JIR.S128292PubMedID: 28405169OAI: oai:DiVA.org:liu-145062DiVA, id: diva2:1181327
Available from: 2018-02-08 Created: 2018-02-08 Last updated: 2018-03-09

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Persson, Hans Lennart

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Sioutas, ApostolosVainikka, LindaJacobson, PetraPersson, Hans Lennart
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Division of Cardiovascular MedicineFaculty of Medicine and Health SciencesDepartment of Respiratory MedicineDivision of Cell BiologyDepartment of Medical and Health Sciences
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Journal of Inflammation Research
Immunology

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