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Differences in levels of albumin, ALT, AST, gamma-GT and creatinine in frail, moderately healthy and healthy elderly individuals
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in Finspång, Health care Center Finspång.
Linköping University, Department of Medical and Health Sciences, Division of Nursing Science. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Social and Welfare Studies, Division of Nursing Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in East Östergötland, Center of Palliative Care.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in Central Östergötland, Department of Acute Internal Medicine and Geriatrics.
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2018 (English)In: Clinical Chemistry and Laboratory Medicine, ISSN 1434-6621, E-ISSN 1437-4331, Vol. 56, no 3, p. 471-478Article in journal (Refereed) Published
Abstract [en]

Background: Reference intervals are widely used as decision tools, providing the physician with information about whether the analyte values indicate ongoing disease process. Reference intervals are generally based on individuals without diagnosed diseases or use of medication, which often excludes elderly. The aim of the study was to assess levels of albumin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine and gamma-glutamyl transferase (gamma-GT) in frail, moderately healthy and healthy elderly indivuduals. Methods: Blood samples were collected from individuals amp;gt; 80 years old, nursing home residents, in the Elderly in Linkoping Screening Assessment and Nordic Reference Interval Project, a total of 569 individuals. They were divided into three cohorts: frail, moderately healthy and healthy, depending on cognitive and physical function. Albumin, ALT, AST, creatinine and gamma-GT were analyzed using routine methods. Results: Linear regression predicted factors for 34% of the variance in albumin were activities of daily living (ADL), gender, stroke and cancer. ADLs, gender and weight explained 15% of changes in ALT. For AST levels, ADLs, cancer and analgesics explained 5% of changes. Kidney disease, gender, Mini Mental State Examination (MMSE) and chronic obstructive pulmonary disease explained 25% of the variation in creatinine levels and MMSE explained three per cent of gamma-GT variation. Conclusions: Because a group of people are at the same age, they should not be assessed the same way. To interpret results of laboratory tests in elderly is a complex task, where reference intervals are one part, but far from the only one, to take into consideration.

Place, publisher, year, edition, pages
WALTER DE GRUYTER GMBH , 2018. Vol. 56, no 3, p. 471-478
Keywords [en]
aging; analyte; clinical interpretation; frail; reference interval
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Clinical Laboratory Medicine
Identifiers
URN: urn:nbn:se:liu:diva-145114DOI: 10.1515/cclm-2017-0311ISI: 000423681100022PubMedID: 28988219OAI: oai:DiVA.org:liu-145114DiVA, id: diva2:1182239
Note

Funding Agencies|Landstinget i Ostergotland Sverige [LIO-359661]

Available from: 2018-02-12 Created: 2018-02-12 Last updated: 2018-03-06

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Sund-Levander, MärthaMilberg, Anna

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Edvardsson, MariaSund-Levander, MärthaMilberg, AnnaWressle, EwaMarcusson, JanGrodzinsky, Ewa
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Division of Drug ResearchFaculty of Medicine and Health SciencesHealth care Center FinspångDivision of Nursing ScienceDivision of Nursing ScienceCenter of Palliative CareDivision of Neuro and Inflammation ScienceDepartment of Acute Internal Medicine and Geriatrics
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